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伪装成急性横贯性脊髓炎的产后低铜性脊髓病:一例报告及罕见表现的文献综述

Postpartum Hypocupric Myelopathy Masquerading as Acute Transverse Myelitis: A Case Report and Literature Review of a Rare Presentation.

作者信息

Pantbalekundri Nikhil, Kumar Sunil, Acharya Sourya, Bedi Gautam

机构信息

Department of General Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.

出版信息

Cureus. 2024 Jan 12;16(1):e52149. doi: 10.7759/cureus.52149. eCollection 2024 Jan.

DOI:10.7759/cureus.52149
PMID:38344647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10858993/
Abstract

The symptoms of transverse myelitis, an acute demyelinating inflammatory condition of the spinal cord, include motor, sensory, and bowel-bladder dysfunction that can develop suddenly or gradually. Several etiologies, such as bacterial, fungal, or viral infections, cancer, autoimmune diseases, vascular problems, and environmental variables, can cause it. The identification of copper deficiency myelopathy (CDM) as a curable cause of non-compressive inflammatory myelopathy has only occurred recently. Patients frequently present with sensory complaints and a spastic gait. The neurological disease may exist independently of the hematologic signs. Only a few cases of copper myelopathy in peripartum women have been documented. Given that hypocupric myelopathy is a treatable cause of debilitating paraplegia, maintaining clinical vigilance will be crucial in minimizing neurological sequelae, as demonstrated in this case report.

摘要

横贯性脊髓炎是脊髓的一种急性脱髓鞘性炎症性疾病,其症状包括运动、感觉及膀胱直肠功能障碍,这些症状可突然或逐渐出现。多种病因,如细菌、真菌或病毒感染、癌症、自身免疫性疾病、血管问题及环境因素等,均可导致该病。铜缺乏性脊髓病(CDM)作为非压迫性炎症性脊髓病的一种可治愈病因,直到最近才被发现。患者常表现出感觉异常及痉挛性步态。该神经疾病可能独立于血液学体征存在。围产期女性铜缺乏性脊髓病的病例记录仅有少数。鉴于低铜性脊髓病是导致使人衰弱的截瘫的一种可治疗病因,保持临床警惕对于将神经后遗症降至最低至关重要,本病例报告即证明了这一点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/10858993/d16614bc760e/cureus-0016-00000052149-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/10858993/d16614bc760e/cureus-0016-00000052149-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/10858993/d16614bc760e/cureus-0016-00000052149-i01.jpg

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本文引用的文献

1
Fatal Acute Disseminated Encephalomyelitis Post-COVID-19 Vaccination: A Rare Case Report.新冠疫苗接种后发生的致命性急性播散性脑脊髓炎:一例罕见病例报告
Cureus. 2022 Nov 22;14(11):e31810. doi: 10.7759/cureus.31810. eCollection 2022 Nov.
2
Copper deficiency related myelopathy 40 years following a jejunoileal bypass.空肠回肠旁路术后40年出现的铜缺乏相关性脊髓病
Spinal Cord Ser Cases. 2019 Dec 16;5:104. doi: 10.1038/s41394-019-0249-x. eCollection 2019.
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Copper deficiency myelopathy: A report of two cases.铜缺乏性脊髓病:两例报告。
J Spinal Cord Med. 2015 Jul;38(4):559-62. doi: 10.1179/2045772314Y.0000000268. Epub 2014 Oct 24.
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Metabolic, nutritional, and toxic myelopathies.代谢性、营养性和中毒性脊髓病。
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Acute transverse myelitis: demyelinating, inflammatory, and infectious myelopathies.急性横贯性脊髓炎:脱髓鞘性、炎症性和感染性脊髓病。
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Subacute combined degeneration of the spinal cord despite prophylactic vitamin B12 treatment.脊髓亚急性联合变性,尽管进行了预防性维生素 B12 治疗。
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Acute and bilateral blindness due to optic neuropathy associated with copper deficiency.与铜缺乏相关的视神经病变导致的急性双侧失明。
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Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease.假牙护理膏:过量锌的一种不寻常来源,可导致低铜血症和神经疾病。
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