Nanozyme Medical Center, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Biomacromolecules (CAS), CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
J Mater Chem B. 2024 Mar 6;12(10):2459-2470. doi: 10.1039/d3tb02819d.
Leukemia is a type of clonal disorder of hematopoietic stem and progenitor cells characterized by bone marrow failure, differentiation arrest, and lineage skewing. Despite leukemia being a complex disease and it being difficult to identify a single driving force, redox homeostasis, the balance between reactive oxygen species (ROS) producers and cellular antioxidant systems, is normally impaired during leukemogenesis. In this context, the modulation of ROS in leukemia cells can be harnessed for therapeutic purposes. Nanozymes are functional nanomaterials with enzyme-like characteristics, which address the intrinsic limitations of natural enzymes and exhibit great potential in synergistic antitumor therapy. Nanozymes possess catalytic activities (, peroxidase-like activity, catalase-like activity, superoxide dismutase-like activity, and oxidase-like activity) to regulate ROS levels and , making them promising for leukemia therapy. On account of the rapid development of nanozymes recently, their application potentials in leukemia therapy are gradually being explored. To highlight the achievements of nanozymes in the leukemia field, this review summarizes the recent studies of nanozymes with anti-leukemia efficacy and the underlying mechanism. In addition, the challenges and prospects of nanozyme research in leukemia therapy are discussed.
白血病是一种造血干/祖细胞克隆性疾病，其特征为骨髓衰竭、分化阻滞和谱系偏倚。尽管白血病是一种复杂的疾病，很难确定单一的驱动因素，但在白血病发生过程中，氧化还原稳态（ROS 产生者和细胞抗氧化系统之间的平衡）通常会受到损害。在这种情况下，白血病细胞中 ROS 的调节可被用于治疗目的。纳米酶是具有酶样特性的功能纳米材料，解决了天然酶的固有局限性，并在协同抗肿瘤治疗中表现出巨大的潜力。纳米酶具有催化活性（如过氧化物酶样活性、过氧化氢酶样活性、超氧化物歧化酶样活性和氧化酶样活性）来调节 ROS 水平[1,2]，使其成为治疗白血病的有前途的方法。鉴于纳米酶最近的快速发展，其在白血病治疗中的应用潜力正在逐渐被探索。为了突出纳米酶在白血病领域的成就，本综述总结了具有抗白血病功效的纳米酶的最新研究及其潜在机制。此外，还讨论了纳米酶在白血病治疗中的研究面临的挑战和前景。
