Further observation on the denervation supersensitivity of the urethra in patients with chronic neurogenic bladders.

The response of the urethra in patients with chronic neurogenic bladders to autonomic stimulation was investigated by urethral pressure profile. A consistent supersensitivity to alpha-adrenergic stimulation was documented. Experiments with various autonomic blocking drugs confirmed that this response is alpha-adrenergically mediated via the short neuron system. The results appear to offer pharmacological evidence for the recently evolving intricate innervation pattern of the urethra including its distal portion, where the alpha-adrenergic system is believed to be important.