升高的嗜酸性粒细胞与淋巴细胞比值、嗜酸性粒细胞与中性粒细胞比值、嗜酸性粒细胞与单核细胞比值与重症白癜风的相关性：一项回顾性队列研究。
Determination of elevated eosinophil to lymphocyte ratio, eosinophil to neutrophil ratio, eosinophil to monocyte ratio and its association with severe vitiligo: A retrospective cohort study.
机构信息
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Clinical Research Unit, Soroka University Medical Center, Beer Sheva, Israel.
出版信息
PLoS One. 2024 Feb 12;19(2):e0296626. doi: 10.1371/journal.pone.0296626. eCollection 2024.
BACKGROUND
Hematological markers such as eosinophil-to-lymphocyte (ELR), eosinophil-to-neutrophil (ENR), and eosinophil-to-monocyte (EMR) ratios may be used in the assessment of skin diseases. However, the relationship with vitiligo remains unclear.
OBJECTIVES
We investigated ELR, ENR, and EMR in vitiligo patients and the association with severe vitiligo.
METHODS
This study included patients of all ages diagnosed with vitiligo between 2005-2020. ELR, EMR, and ENR were calculated from complete blood counts within 30 days of the first recorded vitiligo diagnosis and 12-18 months before the vitiligo diagnosis. We evaluated the associations between ELR, ENR, and EMR and vitiligo.
RESULTS
9,826 vitiligo patients (8,398 adults and 1,428 children) and 8,951 age and sex-matched controls were included in this study. We found that ELR, EMR, and ENR were higher in children than in adults. Patients with vitiligo had higher ENR and EMR than their matched controls. Patients with severe vitiligo had higher ELR, ENR, and EMR compared to patients with mild vitiligo. Patients with increased ENR and EMR 12-18 months before the vitiligo diagnosis had a higher chance of having severe vitiligo (ENR: OR = 7.40, p<0.001, EMR: OR = 3.17, p<0.001).
CONCLUSION
ELR, ENR, and EMR may be used in the assessment and prognosis of vitiligo, especially in severe cases.
背景
嗜酸性粒细胞与淋巴细胞（ELR）、嗜酸性粒细胞与中性粒细胞（ENR）和嗜酸性粒细胞与单核细胞（EMR）比值等血液学标志物可用于评估皮肤病。然而，它们与白癜风的关系尚不清楚。
目的
我们研究了白癜风患者的 ELR、ENR 和 EMR 及其与严重白癜风的关系。
方法
本研究纳入了 2005 年至 2020 年间诊断为白癜风的所有年龄段的患者。在首次记录白癜风诊断后 30 天内和白癜风诊断前 12-18 个月内，通过全血细胞计数计算 ELR、EMR 和 ENR。我们评估了 ELR、ENR 和 EMR 与白癜风之间的关系。
结果
本研究共纳入了 9826 例白癜风患者（8398 例成人和 1428 例儿童）和 8951 名年龄和性别匹配的对照者。我们发现，儿童的 ELR、EMR 和 ENR 高于成人。白癜风患者的 ENR 和 EMR 高于其匹配对照者。与轻度白癜风患者相比，严重白癜风患者的 ELR、ENR 和 EMR 更高。在白癜风诊断前 12-18 个月，ENR 和 EMR 升高的患者发生严重白癜风的几率更高（ENR：OR=7.40，p<0.001，EMR：OR=3.17，p<0.001）。
结论
ELR、ENR 和 EMR 可用于评估和预测白癜风，尤其是严重病例。
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