血液学比率升高与痤疮严重程度相关：一项全国性回顾性队列研究。
Elevated hematologic ratios are correlated with acne severity: a national, retrospective cohort study.
作者信息
Wiesel Vered, Weissmann Sarah, Cohen Bracha, Golan-Tripto Inbal, Horev Amir
机构信息
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Clinical Research Unit, Soroka University Medical Center, Beer Sheva, Israel.
出版信息
Front Med (Lausanne). 2024 Oct 31;11:1475117. doi: 10.3389/fmed.2024.1475117. eCollection 2024.
BACKGROUND
Prior studies demonstrated conflicting results regarding hematologic ratios in acne patients. We sought to further characterize hematologic ratios in acne patients, according to demographics and acne severity.
METHODS
National, retrospective cohort study of 122,822 patients using medical records from 2005 to 2024 of patients insured with the largest public healthcare organization in Israel, Clalit Health Maintenance Organization.
RESULTS
Moderate-severe acne patients had higher neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) than mild acne patients at diagnosis and 12-18 months before diagnosis. A multivariable regression confirmed the significance of the correlation of increased NLR and PLR with acne severity. Adults and females had higher NLR and PLR than children and males, respectively, at diagnosis, and 12-18 months before diagnosis.
CONCLUSION
Acne severity was significantly associated with elevated NLR and PLR. NLR and PLR may also serve as indicators of upcoming acne severity, as they were elevated 12-18 months before diagnosis. These biomarkers may contribute to the diagnosis, management, and follow-up of patients with acne.
背景
先前的研究在痤疮患者血液学指标方面得出了相互矛盾的结果。我们试图根据人口统计学特征和痤疮严重程度，进一步明确痤疮患者的血液学指标特征。
方法
利用以色列最大的公共医疗保健机构——克拉利特健康维护组织2005年至2024年的患者病历，对122,822名患者进行全国性回顾性队列研究。
结果
在诊断时以及诊断前12 - 18个月，中重度痤疮患者的中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）均高于轻度痤疮患者。多变量回归证实了NLR和PLR升高与痤疮严重程度之间相关性的显著性。在诊断时以及诊断前12 - 18个月，成人的NLR高于儿童，女性的PLR高于男性。
结论
痤疮严重程度与NLR和PLR升高显著相关。NLR和PLR也可能作为即将出现的痤疮严重程度的指标，因为它们在诊断前12 - 18个月就已升高。这些生物标志物可能有助于痤疮患者的诊断、管理和随访。
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