Çekici Yusuf, Yılmaz Mücahid, Seçen Özlem
Department of Cardiology, Gaziantep Dr. Ersin Arslan Education and Research Hospital, Gaziantep, Turkey.
Department of Cardiology, Elazığ Education and Research Hospital, Elazığ, Turkey.
J Int Med Res. 2019 Sep;47(9):4292-4303. doi: 10.1177/0300060519862077. Epub 2019 Jul 18.
Smoking has been proven to increase systemic inflammation in previous studies using different biomarkers. The eosinophil-to-lymphocyte ratio (ELR), neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR) are new indicators of systemic inflammation that are used as predictors of systemic inflammation, morbidity, and mortality associated with many diseases. We investigated the effects of smoking on these inflammatory indicators.
In total, 616 consecutive smoking healthy subjects and 387 age-matched nonsmoking healthy subjects were enrolled. White blood cell counts (neutrophils, lymphocytes, basophils, eosinophils, and monocytes) were determined by electrical impedance with an automatic blood cell counting device. The ELR, LMR, and NLR were calculated based on these cell counts. Smoking habits of participants were calculated as pack/year.
The NLR and ELR were significantly higher and the LMR was significantly lower in smokers than nonsmokers. The pack-years were positively correlated with the NLR and ELR and negatively correlated with the LMR.
A high NLR and ELR and low LMR are associated with cigarette smoking and may be useful indicators of systemic inflammation activity, even in healthy smokers. Smokers with a high NLR and ELR and low LMR can easily be identified during routine blood analysis and might benefit from preventive treatment.
在以往使用不同生物标志物的研究中，吸烟已被证实会增加全身炎症反应。嗜酸性粒细胞与淋巴细胞比值（ELR）、中性粒细胞与淋巴细胞比值（NLR）以及淋巴细胞与单核细胞比值（LMR）是全身炎症反应的新指标，可作为许多疾病相关的全身炎症反应、发病率和死亡率的预测指标。我们研究了吸烟对这些炎症指标的影响。
共纳入616名连续的吸烟健康受试者和387名年龄匹配的非吸烟健康受试者。使用自动血细胞计数仪通过电阻抗法测定白细胞计数（中性粒细胞、淋巴细胞、嗜碱性粒细胞、嗜酸性粒细胞和单核细胞）。根据这些细胞计数计算ELR、LMR和NLR。参与者的吸烟习惯以包年计算。
吸烟者的NLR和ELR显著高于非吸烟者，LMR显著低于非吸烟者。吸烟包年数与NLR和ELR呈正相关，与LMR呈负相关。
高NLR和ELR以及低LMR与吸烟有关，即使在健康吸烟者中，也可能是全身炎症活动的有用指标。在常规血液分析中可以很容易地识别出NLR和ELR高且LMR低的吸烟者，他们可能会从预防性治疗中受益。
