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在一家三级癌症中心检测和管理围手术期高血糖症。

Detection and Management of Perioperative Hyperglycemia at a Tertiary Cancer Center.

机构信息

Department of Gynecologic Oncology and Reproductive Medicine, M. D. Anderson Cancer Center, Houston, USA.

Department of Biostatistics, M. D. Anderson Cancer Center, Houston, USA.

出版信息

Ann Surg Oncol. 2024 May;31(5):3017-3023. doi: 10.1245/s10434-024-14986-7. Epub 2024 Feb 12.

Abstract

INTRODUCTION

To improve the detection and management of perioperative hyperglycemia at our tertiary cancer center, we implemented a glycemic control quality improvement initiative. The primary goal was to decrease the percentage of diabetic patients with median postoperative glucose levels > 180 mg/dL during hospitalization by 15% within 2 years.

METHODS

A multidisciplinary team standardized preoperative screening, preoperative, intraoperative, and postoperative hyperglycemia management. We included all patients undergoing nonemergent inpatient and outpatient operations. We used a t test, rank sum, chi-square, or Fisher's exact test to assess differences in outcomes between patients at baseline (BL) (10/2018-4/2019), during the first phase (P1) (10/2019-4/2020), second phase (P2) (5/2020-12/2020), and maintenance phase (M) (1/2021-10/2022).

RESULTS

The analysis included 9891 BL surgical patients (1470 with diabetes), 8815 P1 patients (1233 with diabetes), 10,401 P2 patients (1531 with diabetes) and 30,410 M patients (4265 with diabetes). The percentage of diabetic patients with median glucose levels >180 mg/dL during hospitalization decreased 32% during the initiative (BL, 20.1%; P1, 16.9%; P2, 12.1%; M, 13.7% [P < .001]). We also saw reductions in the percentages of diabetic patients with median glucose levels >180 mg/dL intraoperatively (BL, 34.0%; P1, 26.6%; P2, 23.9%; M, 20.3% [P < .001]) and in the postanesthesia care unit (BL, 36.0%; P1, 30.4%; P2, 28.5%; M, 25.8% [P < .001]). The percentage of patients screened for diabetes by hemoglobin A1C increased during the initiative (BL, 17.5%; P1, 52.5%; P2, 66.8%; M 74.5% [P < .001]).

CONCLUSIONS

Our successful initiative can be replicated in other hospitals to standardize and improve glycemic control among diabetic surgical patients.

摘要

简介

为了提高我们的三级癌症中心围手术期高血糖的检测和管理水平,我们实施了一项血糖控制质量改进计划。主要目标是在 2 年内将住院期间中位术后血糖水平>180mg/dL 的糖尿病患者比例降低 15%。

方法

一个多学科团队对术前筛查、术中、术后高血糖管理进行了标准化。我们纳入了所有接受非紧急住院和门诊手术的患者。我们使用 t 检验、秩和检验、卡方检验或 Fisher 确切检验来评估基线(BL)(2018 年 10 月至 2019 年 4 月)、第一阶段(P1)(2019 年 10 月至 2020 年 4 月)、第二阶段(P2)(2020 年 5 月至 2020 年 12 月)和维持阶段(M)(2021 年 1 月至 2022 年 10 月)患者之间的结果差异。

结果

分析纳入了 9891 例 BL 手术患者(1470 例糖尿病患者)、8815 例 P1 患者(1233 例糖尿病患者)、10401 例 P2 患者(1531 例糖尿病患者)和 30410 例 M 患者(4265 例糖尿病患者)。住院期间中位血糖水平>180mg/dL 的糖尿病患者比例在该计划实施期间降低了 32%(BL:20.1%;P1:16.9%;P2:12.1%;M:13.7%[P<.001])。我们还观察到术中中位血糖水平>180mg/dL 的糖尿病患者比例降低(BL:34.0%;P1:26.6%;P2:23.9%;M:20.3%[P<.001])和麻醉后护理单元(BL:36.0%;P1:30.4%;P2:28.5%;M:25.8%[P<.001])的比例降低。接受血红蛋白 A1C 筛查的糖尿病患者比例在该计划实施期间增加(BL:17.5%;P1:52.5%;P2:66.8%;M:74.5%[P<.001])。

结论

我们成功的计划可以在其他医院复制,以标准化和改善糖尿病手术患者的血糖控制。

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