Esakki Amba, Ramadoss Ramya, Ananthapadmanabhan Lakshmi, Sundar Sandhya, Panneerselvam Suganya, Ramani Pratibha
Dentistry, Saveetha Dental College and Hospitals, Chennai, IND.
Oral Pathology and Oral Biology, Saveetha Dental College and Hospitals, Chennai, IND.
Cureus. 2024 Apr 27;16(4):e59174. doi: 10.7759/cureus.59174. eCollection 2024 Apr.
Allium cepa, or onion, boosts numerous health benefits, including anti-diabetic effects. Its rich array of antioxidants and sulfur compounds not only aids heart health by lowering cholesterol and blood pressure but also exhibits anti-inflammatory properties. Onion's antibacterial and antiviral properties help combat infections, while its compounds like quercetin show promise in cancer prevention. Additionally, Allium cepa supports respiratory health by relieving coughs and colds and aids digestion with its prebiotic properties. Incorporating onions into a balanced diet can enhance overall well-being, including managing blood sugar levels in individuals with diabetes.
This study aims to determine if the ethanolic extract from the dried peel of Allium cepa holds potential as an anti-diabetic agent, with a focus on its ability to manage diabetes and reduce blood sugar levels.
To prepare the ethanolic extract from dried onion peel, the peel was finely ground and soaked in ethanol. The mixture was then agitated and filtered to separate the liquid extract. Finally, the filtrate was concentrated using methods such as rotary evaporation or vacuum distillation to obtain a concentrated extract for further analysis like alpha-amylase inhibition assay and alpha-glucosidase inhibition assay.
The ethanolic extracts derived from dried onion peel demonstrate inhibition of alpha-glucosidase, leading to reduced blood glucose levels. Additionally, this inhibition prompts an increase in insulin production.
The study underscores that the efficacy of the ethanolic extract of dried onion peel increases with concentration. It highlights the presence of beneficial compounds like total phenolics, flavonoids, quercetin, and its derivatives in onion peel, known for their therapeutic roles in cardiovascular health, weight management, diabetes control, cancer prevention, and antimicrobial activity. These findings affirm the hypoglycemic and anti-diabetic properties of Allium cepa's ethanolic leaf extract.
葱属植物洋葱具有诸多健康益处，包括抗糖尿病作用。其丰富的抗氧化剂和硫化合物不仅通过降低胆固醇和血压来促进心脏健康，还具有抗炎特性。洋葱的抗菌和抗病毒特性有助于对抗感染，而其槲皮素等化合物在癌症预防方面显示出前景。此外，洋葱通过缓解咳嗽和感冒来支持呼吸道健康，并因其益生元特性有助于消化。将洋葱纳入均衡饮食可以提高整体健康水平，包括控制糖尿病患者的血糖水平。
本研究旨在确定葱属植物洋葱干燥外皮的乙醇提取物是否具有作为抗糖尿病药物的潜力，重点关注其控制糖尿病和降低血糖水平的能力。
为了从干燥的洋葱皮中制备乙醇提取物，将洋葱皮精细研磨并浸泡在乙醇中。然后搅拌混合物并过滤以分离液体提取物。最后，使用旋转蒸发或真空蒸馏等方法浓缩滤液，以获得浓缩提取物用于进一步分析，如α-淀粉酶抑制试验和α-葡萄糖苷酶抑制试验。
从干燥洋葱皮中提取的乙醇提取物显示出对α-葡萄糖苷酶的抑制作用，导致血糖水平降低。此外，这种抑制作用促使胰岛素分泌增加。
该研究强调干燥洋葱皮乙醇提取物的功效随浓度增加而增强。它突出了洋葱皮中存在总酚、黄酮类化合物、槲皮素及其衍生物等有益化合物，这些化合物以其在心血管健康、体重管理、糖尿病控制、癌症预防和抗菌活性方面的治疗作用而闻名。这些发现证实了葱属植物洋葱乙醇叶提取物的降血糖和抗糖尿病特性。
