Kaiser Permanente Colorado Institute for Health Research, Denver, Colorado, USA.
Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Nutr Cancer. 2024;76(4):352-355. doi: 10.1080/01635581.2024.2316934. Epub 2024 Feb 12.
We aimed to evaluate differences in dietary factors between young-onset (diagnosed at ages <50) and older-onset colorectal cancer (CRC). CRC patients diagnosed from 1998 to 2018 reported to the Puget Sound Surveillance, Epidemiology, and End Results registry were recruited using mail and telephone. Consented patients completed questionnaires assessing demographics, medical history, and CRC risk factors, including dietary factors. We used multi-variable logistic regression to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) comparing dietary intake in young-onset vs. older-onset CRC. Analyses included 1,087 young- and 2,554 older-onset CRC patients. Compared to older-onset CRC, young-onset CRC patients had lower intake of vegetables (OR for highest intake vs. lowest = 0.59 CI: 0.55, 0.64) and fruit (OR for highest intake vs. lowest = 0.94 CI: 0.88, 0.99) and higher intake of processed meat (OR for highest intake vs. lowest = 1.82 CI: 1.11, 2.99) and spicy food (OR for highest intake vs. lowest = 1.69 CI: 1.09, 2.61). There was no statistically significant difference between young- and older-onset CRC patients for red meat consumption. Dietary patterns differed between young- and older-onset CRC; young-onset CRC patients had lower intake of vegetables and fruit and higher intakes of processed meat and spicy food.
我们旨在评估早发性（<50 岁诊断）和晚发性结直肠癌（CRC）之间饮食因素的差异。通过邮件和电话招募了自 1998 年至 2018 年在普吉特湾监测、流行病学和结果登记处诊断为 CRC 的患者。同意参与的患者完成了调查问卷，评估了人口统计学、病史和 CRC 风险因素，包括饮食因素。我们使用多变量逻辑回归计算了早发性与晚发性 CRC 之间饮食摄入的调整比值比（OR）和 95%置信区间（CI）。分析包括 1087 例早发性和 2554 例晚发性 CRC 患者。与晚发性 CRC 相比，早发性 CRC 患者蔬菜摄入量较低（最高与最低摄入量的比值比=0.59，CI：0.55，0.64），水果摄入量较低（最高与最低摄入量的比值比=0.94，CI：0.88，0.99），加工肉类摄入量较高（最高与最低摄入量的比值比=1.82，CI：1.11，2.99），辛辣食物摄入量较高（最高与最低摄入量的比值比=1.69，CI：1.09，2.61）。早发性和晚发性 CRC 患者的红肉摄入量没有统计学上的显著差异。早发性和晚发性 CRC 患者的饮食模式存在差异；早发性 CRC 患者蔬菜和水果摄入量较低，加工肉类和辛辣食物摄入量较高。
