Department of Dermatology, General Hospital of Northern Theater Command, Shenyang, China.
Front Immunol. 2024 Jan 29;15:1345646. doi: 10.3389/fimmu.2024.1345646. eCollection 2024.
Dermatomyositis (DM) is a type of inflammatory myopathy with unknown causes. It is characterized by distinct skin lesions, weakness in the muscles close to the body, and the potential to affect multiple organs. Additionally, it may be associated with the presence of malignancies. The development of DM is influenced by genetic susceptibility, autoimmune response, and various external factors like cancer, drugs, and infectious agents. Psoriasis is a chronic, recurring, inflammatory, and systemic condition. Scaly erythema or plaque is the typical skin manifestation. The etiology of psoriasis involves genetic, immune, environmental and other factors. It is uncommon for a patient to have both of these diseases simultaneously, although individuals with DM may occasionally exhibit symptoms similar to those of psoriasis. Our patient was diagnosed with psoriasis in his 50s because of scalp squamous plaques, but he did not receive standard treatment. Ten years later, he developed symptoms of muscle pain and limb weakness. He was diagnosed with psoriasis complicated with dermatomyositis in our department and received corresponding treatment. Moreover, we reviewed the relevant literature to evaluate similarities and differences in clinical manifestation and treatment to other cases.
皮肌炎(DM)是一种病因不明的炎症性肌病。其特征是具有独特的皮肤损伤、靠近身体的肌肉无力,并可能影响多个器官。此外,它可能与恶性肿瘤的存在有关。DM 的发生受到遗传易感性、自身免疫反应和多种外部因素(如癌症、药物和感染因子)的影响。银屑病是一种慢性、复发性、炎症性和全身性疾病。鳞屑性红斑或斑块是其典型的皮肤表现。银屑病的病因涉及遗传、免疫、环境等多种因素。虽然 DM 患者偶尔可能会出现类似于银屑病的症状,但同时患有这两种疾病的情况并不常见。我们的患者在 50 多岁时因头皮鳞状斑块而被诊断出患有银屑病,但未接受标准治疗。十年后,他出现肌肉疼痛和四肢无力的症状。他在我们科被诊断为银屑病合并皮肌炎,并接受了相应的治疗。此外,我们还回顾了相关文献,以评估与其他病例在临床表现和治疗方面的异同。