Vahiddastjerdi Mehdi, Vaghar Mohammad Eslami, Dashtaki Shiva Gholami
Department of Neurology, Faculty of Medicine, Tehran Medical Sciences,Islamic Azad University, Tehran, Iran.
Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Maedica (Bucur). 2023 Dec;18(4):593-597. doi: 10.26574/maedica.2023.18.4.593.
Until now, there have been few investigations on the efficacy of fosfomycin in the treatment of patients with uncomplicated urinary tract infections (UTIs). The present study is aimed to examine how fosfomycin affects females with lower UTIs. A total of 200 female patients who visited the women's clinic at Amir-Al-Momenin Hospital between 2020 and 2021 were examined in the present study. Patients were randomly divided into two groups of 100 people each, with one group receiving fosfomycin (a single 3 g dose) and the other one receiving cephalexin (a five-day regimen at 0.5 g four times daily). Then, one week and one month after treatment, the patients underwent a urine culture test. The data were collected and further analyzed in SPSS statistics software version 26. According to the study findings, the mean age of females suffering from lower UTI was 25.45 ± 5.85 years. Besides, the collected data revealed that 85.5% of females diagnosed with lower UTI had E. coli. In addition, the frequency of females with Staphylococcus saprophyticus, Proteus spp and Klebsiella were 9%, 3% and 2.5%, respectively. Also, the frequency of women with UTI for E. coli, Staphylococcus saprophyticus, Proteus spp and Klebsiella were 85.5%, 9%, 3.2% and 2.5%, respectively. One month after treatment, urine culture showed positive results in 98% of patients who were treated with fosfomycin and 95% of those who received cephalexin. Fosfomycin can be administrated to treat uncomplicated UTIs in women with a high level of confidence, as an alternative to cephalexin.
到目前为止，关于磷霉素治疗单纯性尿路感染（UTIs）患者疗效的研究很少。本研究旨在探讨磷霉素如何影响患有下尿路感染的女性。本研究对2020年至2021年间在阿米尔-穆民宁医院妇科门诊就诊的200名女性患者进行了检查。患者被随机分为两组，每组100人，一组接受磷霉素（单次3g剂量），另一组接受头孢氨苄（0.5g，每日4次，疗程5天）。然后，在治疗后1周和1个月，患者接受尿培养检查。数据收集后在SPSS统计软件26版中进行进一步分析。根据研究结果，患有下尿路感染的女性平均年龄为25.45±5.85岁。此外，收集的数据显示，85.5%被诊断为下尿路感染的女性感染了大肠杆菌。此外，腐生葡萄球菌、变形杆菌属和克雷伯菌属女性患者的感染率分别为9%、3%和2.5%。同样，大肠杆菌、腐生葡萄球菌、变形杆菌属和克雷伯菌属引起的尿路感染女性患者的感染率分别为85.5%、9%、3.2%和2.5%。治疗1个月后，接受磷霉素治疗的患者中98%尿培养呈阳性，接受头孢氨苄治疗的患者中95%尿培养呈阳性。作为头孢氨苄的替代药物，磷霉素可用于治疗女性单纯性尿路感染，且具有较高的可信度。
