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首例使用纯化羊水加速顽固性糖尿病溃疡愈合的病例

First Case of Accelerated Healing of a Recalcitrant Diabetic Ulcer Using Purified Amniotic Fluid.

作者信息

Goldschmidt-Clermont Pascal J, White Ian A

机构信息

Neobiosis LLC, UF Sid Martin Innovate Biotechnology Institute, Alachua, FL 32615, USA.

出版信息

Ann Case Rep. 2023;8(5). doi: 10.29011/2574-7754.101463. Epub 2023 Oct 2.

DOI:10.29011/2574-7754.101463
PMID:38348151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10861243/
Abstract

We report the first case of recalcitrant diabetic wound treated successfully by twice-daily applications of a sterile fraction of human purified amniotic fluid (ViX001) obtained from thoroughly screened volunteers at the time of planned c-section at the term of normal pregnancies. Our product ViX001 was generated through a proprietary process and kept in frozen one milliliter (1 ml) vials (protein content was ~1mg/ml) thawed prior to applications (shelf life at 34oF of at least two weeks).

摘要

我们报告了首例顽固性糖尿病伤口通过每日两次应用从正常妊娠足月计划性剖宫产时经过全面筛查的志愿者获得的人纯化羊水无菌组分（ViX001）成功治愈的病例。我们的产品ViX001通过专有工艺制备，保存在冷冻的一毫升（1 ml）小瓶中（蛋白质含量约为1mg/ml），使用前解冻（在34°F下保质期至少为两周）。

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First Case of Accelerated Healing of a Recalcitrant Diabetic Ulcer Using Purified Amniotic Fluid.首例使用纯化羊水加速顽固性糖尿病溃疡愈合的病例
Ann Case Rep. 2023;8(5). doi: 10.29011/2574-7754.101463. Epub 2023 Oct 2.
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First Case of Debilitating Lower Back Pain Induced by Severe Inflammation of Lumbar Joints, Healed by Intravenous Infusions of Purified Amniotic Fluid.首例因腰椎关节严重炎症引发的下背部剧痛，经静脉输注纯化羊水治愈。
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引用本文的文献

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The Striking Power of Amniotic Fluid and Its Exosomes Collected at the End of a Normal Pregnancy on Severe Inflammation and Tissue Repair.正常妊娠末期采集的羊水及其外泌体对严重炎症和组织修复的显著作用。
Ann Case Rep. 2024;9(6). doi: 10.29011/25747754.102099. Epub 2024 Dec 2.
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First Case of Severe Pain and Inflammation Reduction by Application of Purified Amniotic Fluid on Active Lesions of a Patient with Pyoderma Gangrenosum.通过应用纯化羊水减轻坏疽性脓皮病患者活动性皮损严重疼痛和炎症的首例病例。
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First Case of Debilitating Lower Back Pain Induced by Severe Inflammation of Lumbar Joints, Healed by Intravenous Infusions of Purified Amniotic Fluid.首例因腰椎关节严重炎症引发的下背部剧痛，经静脉输注纯化羊水治愈。
Ann Case Rep. 2023;8(6). doi: 10.29011/2574-7754.101509. Epub 2023 Nov 14.

本文引用的文献

1
The role of mesenchymal stem cell-derived EVs in diabetic wound healing.间充质干细胞衍生的细胞外囊泡在糖尿病创面愈合中的作用。
Front Immunol. 2023 Feb 28;14:1136098. doi: 10.3389/fimmu.2023.1136098. eCollection 2023.
2
The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: Trends and prospects.脂肪源性干细胞衍生的细胞外囊泡在糖尿病足溃疡治疗中的作用：趋势与展望。
Front Endocrinol (Lausanne). 2022 Jul 27;13:902130. doi: 10.3389/fendo.2022.902130. eCollection 2022.
3
Pregnancy, a unique case of heterochronic parabiosis and peripartum cardiomyopathy.妊娠，一种异时联体共生和围产期心肌病的独特情况。
Front Biosci (Landmark Ed). 2021 Sep 30;26(9):666-672. doi: 10.52586/4975.
4
Human Amniotic Fluid Stem Cell-Derived Exosomes as a Novel Cell-Free Therapy for Cutaneous Regeneration.人羊水干细胞来源的外泌体作为一种用于皮肤再生的新型无细胞疗法
Front Cell Dev Biol. 2021 Jun 21;9:685873. doi: 10.3389/fcell.2021.685873. eCollection 2021.
5
Differential Therapeutic Effect of Extracellular Vesicles Derived by Bone Marrow and Adipose Mesenchymal Stem Cells on Wound Healing of Diabetic Ulcers and Correlation to Their Cargoes.骨髓间充质干细胞和脂肪间充质干细胞来源的细胞外囊泡对糖尿病溃疡伤口愈合的差异治疗作用及其与囊泡内容物的相关性
Int J Mol Sci. 2021 Apr 8;22(8):3851. doi: 10.3390/ijms22083851.
6
Human amniotic fluid stem cells have a unique potential to accelerate cutaneous wound healing with reduced fibrotic scarring like a fetus.人羊水干细胞具有独特的潜力，可以加速皮肤伤口愈合，减少像胎儿一样的纤维性瘢痕。
Hum Cell. 2019 Jan;32(1):51-63. doi: 10.1007/s13577-018-0222-1. Epub 2018 Dec 1.
7
First Characterization of Human Amniotic Fluid Stem Cell Extracellular Vesicles as a Powerful Paracrine Tool Endowed with Regenerative Potential.首次对人羊膜间充质干细胞细胞外囊泡进行特征描述，认为其是具有再生潜能的强大旁分泌工具。
Stem Cells Transl Med. 2017 May;6(5):1340-1355. doi: 10.1002/sctm.16-0297. Epub 2017 Mar 8.
8
Scarless fetal wound healing: a basic science review.无痕胎儿伤口愈合：基础科学综述。
Plast Reconstr Surg. 2010 Oct;126(4):1172-1180. doi: 10.1097/PRS.0b013e3181eae781.
9
Amniotic fluid: not just fetal urine anymore.羊水：不再仅仅是胎儿的尿液了。
J Perinatol. 2005 May;25(5):341-8. doi: 10.1038/sj.jp.7211290.