Division of Endocrinology, Internal Medicine, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, China.
Laboratory of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, China.
Front Endocrinol (Lausanne). 2022 Jul 27;13:902130. doi: 10.3389/fendo.2022.902130. eCollection 2022.
Diabetic foot ulcer(DFU) is one of the most severe chronic complications of type 2 diabetes mellitus, which is mainly caused by peripheral vascular occlusion with various degrees of infection. Treatment of DFU is difficult, and ulcer formation in lower limbs and deep-tissue necrosis might lead to disability or even death. Insulin resistance is the major mechanism of type 2 diabetes mellitus development, largely caused by adipose tissue dysfunction. However, adipose tissue was recently identified as an important endocrine organ that secretes bio-active factors, such as adipokines and extracellular vesicles(EVs). And adipose tissue-derived stem cells(ADSCs) are abundant in adipose tissue and have become a hot topic in the tissue engineering field. In particular, EVs derived from ADSCs contain abundant biomarkers and mediators. These EVs exert significant effects on distant cells and organs, contributing to metabolic homeostasis. In this review, we aim to elaborate on the mechanisms of diabetic non-healing wound development and the role of ADSCs-EVs in wound repair, which might provide a new therapy for treating DFU.
糖尿病足溃疡（DFU）是 2 型糖尿病最严重的慢性并发症之一，主要由外周血管阻塞伴不同程度的感染引起。DFU 的治疗较为困难，下肢溃疡和深部组织坏死可能导致残疾甚至死亡。胰岛素抵抗是 2 型糖尿病发展的主要机制，主要由脂肪组织功能障碍引起。然而，脂肪组织最近被确定为一个重要的内分泌器官，它分泌生物活性因子，如脂肪因子和细胞外囊泡（EVs）。脂肪组织来源的干细胞（ADSCs）在脂肪组织中丰富，已成为组织工程领域的热门话题。特别是，ADSCs 衍生的 EVs 含有丰富的生物标志物和介质。这些 EVs 对远处的细胞和器官发挥显著作用，有助于代谢平衡。在这篇综述中，我们旨在阐述糖尿病难愈性伤口发展的机制以及 ADSCs-EVs 在伤口修复中的作用，这可能为治疗 DFU 提供一种新的治疗方法。
