Tang Shaokai, Geng Yuanwen, Lin Qinqin
School of Physical Education, Yanshan University, Qinhuangdao, China.
Front Physiol. 2024 Jan 29;15:1339128. doi: 10.3389/fphys.2024.1339128. eCollection 2024.
Mitochondria are energy factories that sustain life activities in the body, and their dysfunction can cause various metabolic diseases that threaten human health. Mitophagy, an essential intracellular mitochondrial quality control mechanism, can maintain cellular and metabolic homeostasis by removing damaged mitochondria and participating in developing metabolic diseases. Research has confirmed that exercise can regulate mitophagy levels, thereby exerting protective metabolic effects in metabolic diseases. This article reviews the role of mitophagy in metabolic diseases, the effects of exercise on mitophagy, and the potential mechanisms of exercise-regulated mitophagy intervention in metabolic diseases, providing new insights for future basic and clinical research on exercise interventions to prevent and treat metabolic diseases.
线粒体是维持机体生命活动的能量工厂，其功能障碍可引发各种威胁人类健康的代谢性疾病。线粒体自噬是一种重要的细胞内线粒体质量控制机制，可通过清除受损线粒体并参与代谢性疾病的发生发展来维持细胞和代谢稳态。研究证实，运动可调节线粒体自噬水平，从而在代谢性疾病中发挥保护性代谢作用。本文综述了线粒体自噬在代谢性疾病中的作用、运动对线粒体自噬的影响以及运动调节线粒体自噬干预代谢性疾病的潜在机制，为未来运动干预预防和治疗代谢性疾病的基础和临床研究提供新的见解。
