细胞因子（白细胞介素1β、白细胞介素6、肿瘤坏死因子α）和血清皮质醇水平可能并非用于识别新冠病毒感染后急性后遗症患者的可靠生物标志物。
Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.
作者信息
Fleischer Michael, Szepanowski Fabian, Mausberg Anne K, Asan Livia, Uslar Ellen, Zwanziger Denise, Volbracht Lothar, Stettner Mark, Kleinschnitz Christoph
机构信息
Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University Duisburg-Essen, Essen, Germany.
Department of Endocrinology, Diabetes and Metabolism, Clinical Chemistry - Division of Laboratory Research, University Medicine Essen, University Duisburg-Essen, Essen, Germany.
出版信息
Ther Adv Neurol Disord. 2024 Feb 12;17:17562864241229567. doi: 10.1177/17562864241229567. eCollection 2024.
BACKGROUND
Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge.
OBJECTIVES
Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words.
DESIGN
This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 ( = 13), infected but had no PASC ( = 34), infected with former PASC that resolved ( = 40) and patients with ongoing PASC after infection ( = 91).
METHODS
Cytokine and cortisol serum levels were determined in patients' blood samples.
RESULTS
Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed.
CONCLUSION
This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked.
背景
新型冠状病毒肺炎（COVID-19）的急性后遗症（PASC）包括一系列广泛的症状，如疲劳、全身无力、注意力不集中、睡眠问题或焦虑症。PASC是一项医学和社会经济挑战。
目的
我们的研究评估了一组典型PASC患者的细胞因子（IL-1β、IL-6和TNFα）和皮质醇水平，这些患者存在注意力不集中、疲劳和语言表达困难等问题。
设计
这是一项前瞻性队列研究。分析并比较了四组：从未感染过严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的人（=13例）、感染但无PASC的人（=34例）、曾感染过PASC但已康复的人（=40例）以及感染后仍患有持续性PASC的患者（=91例）。
方法
测定患者血液样本中的细胞因子和皮质醇血清水平。
结果
分析的各组之间，IL-1β、IL-6、TNFα的细胞因子水平和皮质醇水平没有差异。
结论
这可能表明PASC存在非器质性/心身性发病机制；需要进一步研究以阐明PACS的潜在原因，且不应忽视非器质性原因。
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