Huo Yuping, Huang Yike, Lee Tungchun, Lin Maoying, Chun Wenhung
Department of Dermatology, Xiamen Chang Gung Hospital, Hua Qiao University, Xiamen, Fujian, China.
Department of Dermatology, Linkou Chang-Gung Memorial Hospital, Taiwan, China.
Front Med (Lausanne). 2024 Jan 29;11:1328750. doi: 10.3389/fmed.2024.1328750. eCollection 2024.
While new targeted therapies have advanced psoriasis treatment, real-world data on comparative effectiveness is lacking. This study analyzed treatment regimens and response in an observational cohort, examining potential disparities between clinical trials and routine practice.
Data from the Psoriasis Standardized Diagnosis and Treatment Center registry were analyzed. Patients with ≥1 follow-up were included. Treatment response was assessed using PASI 50/90 criteria. Factors associated with response were analyzed.
407 patients were included (46 first-time diagnosed, 361 previously diagnosed). A higher proportion of first-time diagnosed patients achieved treatment response than previously diagnosed (76.1% vs. 62.6%). Multivariable analysis identified factors associated with reduced response in previously treated patients.
This real-world study found lower treatment response rates compared to clinical trials, especially in previously treated patients. Disparities highlight remaining unmet needs for psoriasis management. Combination and rotational strategies may improve outcomes in patients unresponsive to available therapies. Ongoing research on novel targets and pathways is warranted to address treatment gaps.
虽然新的靶向治疗方法推动了银屑病治疗的进展，但缺乏关于比较疗效的真实世界数据。本研究分析了一个观察性队列中的治疗方案和反应，考察了临床试验与常规实践之间的潜在差异。
分析来自银屑病标准化诊断与治疗中心登记处的数据。纳入有≥1次随访的患者。使用PASI 50/90标准评估治疗反应。分析与反应相关的因素。
纳入407例患者（46例初诊患者，361例既往诊断患者）。初诊患者达到治疗反应的比例高于既往诊断患者（76.1%对62.6%）。多变量分析确定了与既往治疗患者反应降低相关的因素。
这项真实世界研究发现，与临床试验相比，治疗反应率较低，尤其是在既往治疗的患者中。差异凸显了银屑病管理中仍未满足的需求。联合和轮换策略可能改善对现有治疗无反应患者的结局。有必要持续开展关于新靶点和途径的研究以填补治疗空白。
