Sibilia Francesca, Jost-Mousseau Coline, Banaschewski Tobias, Barker Gareth J, Büchel Christian, Desrivières Sylvane, Flor Herta, Grigis Antoine, Garavan Hugh, Gowland Penny, Heinz Andreas, Ittermann Bernd, Martinot Jean-Luc, Martinot Marie-Laure Paillère, Artiges Eric, Nees Frauke, Orfanos Dimitri Papadopoulos, Poustka Luise, Millenet Sabina, Fröhner Juliane H, Smolka Michael N, Walter Henrik, Whelan Robert, Schumann Gunter, Bokde Arun L W
Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Paris Institute of Technology for Life, Food and Environmental Sciences, Paris, France.
IBRO Neurosci Rep. 2024 Feb 1;16:201-210. doi: 10.1016/j.ibneur.2024.01.012. eCollection 2024 Jun.
Adolescence is a crucial period for physical and psychological development. The impact of negative life events represents a risk factor for the onset of neuropsychiatric disorders. This study aims to investigate the relationship between negative life events and structural brain connectivity, considering both graph theory and connectivity strength. A group (n = 487) of adolescents from the IMAGEN Consortium was divided into Low and High Stress groups. Brain networks were extracted at an individual level, based on morphological similarity between grey matter regions with regions defined using an atlas-based region of interest (ROI) approach. Between-group comparisons were performed with global and local graph theory measures in a range of sparsity levels. The analysis was also performed in a larger sample of adolescents (n = 976) to examine linear correlations between stress level and network measures. Connectivity strength differences were investigated with network-based statistics. Negative life events were not found to be a factor influencing global network measures at any sparsity level. At local network level, between-group differences were found in centrality measures of the left somato-motor network (a decrease of betweenness centrality was seen at sparsity 5%), of the bilateral central visual and the left dorsal attention network (increase of degree at sparsity 10% at sparsity 30% respectively). Network-based statistics analysis showed an increase in connectivity strength in the High stress group in edges connecting the dorsal attention, limbic and salience networks. This study suggests negative life events alone do not alter structural connectivity globally, but they are associated to connectivity properties in areas involved in emotion and attention.
青春期是身体和心理发展的关键时期。负面生活事件的影响是神经精神疾病发病的一个风险因素。本研究旨在探讨负面生活事件与大脑结构连通性之间的关系，同时考虑图论和连通性强度。将来自IMAGEN联盟的一组青少年（n = 487）分为低压力组和高压力组。基于灰质区域与使用基于图谱的感兴趣区域（ROI）方法定义的区域之间的形态相似性，在个体水平上提取大脑网络。在一系列稀疏水平下，使用全局和局部图论测量进行组间比较。还在更大的青少年样本（n = 976）中进行分析，以检查压力水平与网络测量之间的线性相关性。使用基于网络的统计方法研究连通性强度差异。未发现负面生活事件在任何稀疏水平上是影响全局网络测量的因素。在局部网络水平上，在左侧躯体运动网络的中心性测量中发现组间差异（在稀疏度为5%时介数中心性降低），在双侧中央视觉和左侧背侧注意网络中也发现差异（分别在稀疏度为10%和30%时度增加）。基于网络的统计分析表明，高压力组中连接背侧注意、边缘和突显网络的边的连通性强度增加。这项研究表明，仅负面生活事件不会在全局上改变结构连通性，但它们与涉及情绪和注意力的区域的连通性属性相关。
