Neuroscience and Pain Research Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi, Uttar Pradesh, India.
Cell Biochem Funct. 2024 Mar;42(2):e3944. doi: 10.1002/cbf.3944.
Apoptosis is the cell's natural intrinsic regulatory mechanism of normal cells for programmed cell death, which plays an important role in cancer as a classical mechanism of tumor cell death causing minimal inflammation without causing damage to other cells in the vicinity. Induction of apoptosis by activation of caspases is one of the primary targets for cancer treatment. Over the years, a diverse range of natural, synthetic, and semisynthetic compounds and their derivatives have been investigated for their caspase-mediated apoptosis-induced anticancer activities. The review aims to compile the preclinical evidence and highlight the critical mechanistic pathways related to caspase-induced cell apoptosis in cancer treatment. The focus is placed on the key components of the mechanisms, including their chemical nature, and specific attention is given to phytochemicals derived from natural sources and synthetic and semisynthetic compounds. 180+ compounds from the past two decades with potential as anticancer agents are discussed in this review article. By summarizing the current knowledge and advancements in this field, this review provides a comprehensive overview of potential therapeutic strategies targeting apoptosis in cancer cells. The findings presented herein contribute to the ongoing efforts to combat cancer and stimulate further research into the development of effective and targeted anticancer therapies.
细胞凋亡是正常细胞程序性细胞死亡的内在固有调节机制，作为肿瘤细胞死亡的经典机制，在癌症中起着重要作用，它引起的最小炎症而不会对附近的其他细胞造成损害。通过激活半胱天冬酶诱导细胞凋亡是癌症治疗的主要靶点之一。多年来，人们研究了各种天然、合成和半合成化合物及其衍生物，以研究它们对半胱天冬酶介导的细胞凋亡诱导的抗癌活性。本综述旨在汇编临床前证据，并强调与 caspase 诱导的细胞凋亡在癌症治疗中的关键机制途径相关的关键机制途径。重点关注机制的关键组成部分，包括其化学性质，并特别关注源自天然来源的植物化学物质和合成及半合成化合物。本文讨论了过去二十年中具有抗癌潜力的 180 多种化合物。通过总结该领域的现有知识和进展，本综述提供了对靶向癌细胞凋亡的潜在治疗策略的全面概述。本文提出的研究结果为对抗癌症和激发进一步研究开发有效和靶向性抗癌疗法提供了贡献。
