Kolenko V M, Uzzo R G, Bukowski R, Finke J H
Department of Immunology, The Cleveland Clinic Foundation, Ohio 44195, USA.
Apoptosis. 2000 Feb;5(1):17-20. doi: 10.1023/a:1009677307458.
The majority of current anticancer therapies induce tumor cell death through the induction of apoptosis. Alterations in the apoptotic pathways may determine tumor resistance to these therapies. Activation of the proteolytic cascade involving caspase family members is a critical component of the execution of cell death in apoptotic cells. However, recent studies suggest that cell death can proceed in the absence of caspases. In this review we describe the role of caspase-dependent and -independent pathways as targets for anticancer treatment. A better understanding of diverse modes of tumor cell death will help to avoid ineffective treatment and provide a molecular basis for the new strategies targeting caspase-independent death pathways in apoptosis-resistant forms of cancer.
目前大多数抗癌疗法通过诱导细胞凋亡来促使肿瘤细胞死亡。凋亡途径的改变可能决定肿瘤对这些疗法的抗性。涉及半胱天冬酶家族成员的蛋白水解级联反应的激活是凋亡细胞中细胞死亡执行的关键组成部分。然而，最近的研究表明，细胞死亡可以在没有半胱天冬酶的情况下发生。在这篇综述中，我们描述了半胱天冬酶依赖性和非依赖性途径作为抗癌治疗靶点的作用。更好地理解肿瘤细胞死亡的多种模式将有助于避免无效治疗，并为针对抗凋亡形式癌症中半胱天冬酶非依赖性死亡途径的新策略提供分子基础。
