Institute of Biochemistry named after H Buniatian, NAS RA, Yerevan 0014, Armenia.
Russian-Armenian University, Yerevan 0051, Armenia.
Nanomedicine (Lond). 2024 Apr;19(8):689-708. doi: 10.2217/nnm-2023-0275. Epub 2024 Feb 13.
The effectiveness of a drug is dependent on its accumulation at the site of therapeutic action, as well as its time in circulation. The aim of the research was the creation of stable albumin/tannin (punicalagin, punicalin) particles, which might serve for the delivery of medicines. Numerous chromatographic and analytical methods, docking analyses and testing were applied and used. Stable tannin-albumin/medicine particles with a diameter of ∼100 nm were obtained. The results of experiments proved that tannin-albumin particles are more stable than albumin particles. Based on the experiments and docking analyses, these stable particles can carry an extended number of medicines, with diverse chemical structures.
药物的疗效取决于其在治疗部位的积累，以及其在循环中的时间。本研究的目的是创建稳定的白蛋白/单宁（鞣花酸、鞣花单宁）颗粒，这些颗粒可能用于药物输送。应用并使用了许多色谱和分析方法、对接分析和测试。获得了直径约为 100nm 的稳定单宁-白蛋白/药物颗粒。实验结果证明，单宁-白蛋白颗粒比白蛋白颗粒更稳定。基于实验和对接分析，这些稳定的颗粒可以携带数量更多、化学结构多样的药物。
