Division of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Ann Hematol. 2024 Jun;103(6):1819-1831. doi: 10.1007/s00277-024-05630-1. Epub 2024 Feb 13.
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), formerly known as 2019-nCoV. Numerous cellular and biochemical issues arise after COVID-19 infection. The severe inflammation that is caused by a number of cytokines appears to be one of the key hallmarks of COVID-19. Additionally, people with severe COVID-19 have coagulopathy and fulminant thrombotic events. We briefly reviewed the COVID-19 disease at the beginning of this paper. The inflammation and coagulation markers and their alterations in COVID-19 illness are briefly discussed in the parts that follow. Next, we talked about NETosis, which is a crucial relationship between coagulation and inflammation. In the end, we mentioned the two-way relationship between inflammation and coagulation, as well as the factors involved in it. We suggest that inflammation and coagulation are integrated systems in COVID-19 that act on each other in such a way that not only inflammation can activate coagulation but also coagulation can activate inflammation.
新型冠状病毒病（COVID-19）是由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起的，以前称为 2019-nCoV。COVID-19 感染后会出现许多细胞和生化问题。大量细胞因子引起的严重炎症似乎是 COVID-19 的关键特征之一。此外，重症 COVID-19 患者存在凝血功能障碍和暴发性血栓事件。本文首先简要回顾了 COVID-19 疾病。接下来的部分简要讨论了 COVID-19 疾病中的炎症和凝血标志物及其变化。接下来，我们讨论了 NETosis，这是凝血和炎症之间的关键关系。最后，我们提到了炎症和凝血之间的双向关系，以及其中涉及的因素。我们认为炎症和凝血是 COVID-19 中的整合系统，它们以相互作用的方式发挥作用，不仅炎症可以激活凝血，而且凝血也可以激活炎症。
