Kastelan M, Rudolf M, Hrsak M, Stojkovic R, Gamulin S
Biomed Pharmacother. 1985;39(8):442-4.
In 60 breast cancer patients in stages I and II the blastogenic transformation of peripheral blood lymphocytes after phytohaemagglutinin (PHA) pokeweed mitogen (PWM) and concanavalin A (Con A) stimulation were assayed and estrogen (ER) and progesterone (PgR) receptor concentrations in tumor cytosol were measured. A negative correlation between lymphocyte reactivity to the mitogens and tumor steroid receptors concentration was found. The lymphocyte response to the mitogens in the patients with ER-PgR-tumors (R-) was significantly higher than in those with tumors either ER+PgR-or ER-PgR+ (R+) or ER+PgR+ (R++). There was also a negative correlation between lymphocyte response to PHA and either ER or PgR concentrations in the tumors. These results suggest that the presence of steroid receptors in tumor cells may be associated with the depression of immunological reactivity in breast cancer patients.
对60例Ⅰ期和Ⅱ期乳腺癌患者，检测了植物血凝素（PHA）、商陆有丝分裂原（PWM）和刀豆球蛋白A（Con A）刺激后外周血淋巴细胞的致有丝分裂转化，并测定了肿瘤细胞溶质中雌激素（ER）和孕激素（PgR）受体浓度。发现淋巴细胞对有丝分裂原的反应性与肿瘤类固醇受体浓度之间呈负相关。ER-PgR-肿瘤（R-）患者的淋巴细胞对有丝分裂原的反应明显高于ER+PgR-或ER-PgR+（R+）或ER+PgR+（R++）肿瘤患者。淋巴细胞对PHA的反应与肿瘤中ER或PgR浓度之间也呈负相关。这些结果表明，肿瘤细胞中类固醇受体的存在可能与乳腺癌患者免疫反应性降低有关。
