Lang B A, Vermousek I, Simicková M, Cernoch M, Nekulová M, Paćovský Z, Rejthar A
Masaryk Memorial Cancer Institute, Brno, Czeck Republic.
Neoplasma. 1997;44(1):53-7.
The concentrations of three steroid hormones (estrogen, progesteron and 1,25-dihydroxycholecalciferol) receptors (ER, PgR, DR) in tissue cytosol were analyzed in a group of 17 breast phylloid tumors. Comparison with breast carcinoma tissue samples (n = 37) did not reveal significant differences in average values of ER, PgR, and DR. Comparison with another control set of 30 samples of dysplastic tissue of the mammary gland showed significant differences only in PgR values. Only 18% of phylloid tumor samples contained levels above cut-of-line of all three receptors (ER, PgR, DR-5,10,10 resp. fmol/ mg protein). The most frequent combination was ER+PgR+DR-(41%). As far as we know, DR in phylloid breast tumors have never been examined before. In approximately 60% of our samples we found the expression of DR, in 36% the estimated values were above 10 fmol/mg protein. Cells of the tissue not expressing DR seem to belong to a special phenotype. We found no ER+PgR- or ER-PgR-combinations in them. The group which expresses DR is characterized by a higher dispersion of PgR values.
对一组17例乳腺叶状肿瘤的组织胞浆中三种甾体激素（雌激素、孕酮和1,25 - 二羟胆钙化醇）受体（ER、PgR、DR）的浓度进行了分析。与乳腺癌组织样本（n = 37）比较，未发现ER、PgR和DR的平均值有显著差异。与另一组30例乳腺发育异常组织样本比较，仅在PgR值上有显著差异。仅18%的叶状肿瘤样本中所有三种受体（ER、PgR、DR分别为5、10、10 fmol/mg蛋白）水平高于临界值。最常见的组合是ER+PgR+DR-（41%）。据我们所知，此前从未对乳腺叶状肿瘤中的DR进行过检测。在我们大约60%的样本中发现了DR的表达，36%的估计值高于10 fmol/mg蛋白。组织中不表达DR的细胞似乎属于一种特殊的表型。在它们当中我们未发现ER+PgR-或ER-PgR-的组合。表达DR的组的特征是PgR值的离散度较高。
