Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard, 165, J109, 8200 Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Boulevard, 11, 8200 Aarhus, Denmark.
Department of Clinical Biochemistry, Aarhus University Hospital, Palle Juul-Jensens Boulevard, 99, 8200 Aarhus, Denmark Aarhus, Denmark.
Diabetes Res Clin Pract. 2023 Nov;205:110988. doi: 10.1016/j.diabres.2023.110988. Epub 2023 Oct 30.
To investigate the relationship between neurofilament light chain (NfL) and the presence and severity of diabetic polyneuropathy (DPN).
We performed cross-sectional analysis of data from 178 participants of the ADDITION-Denmark cohort of people with screen-detected type 2 diabetes and 32 healthy controls. Biobank serum samples were analyzed for NfL using single-molecule array. DPN was defined by Toronto criteria for confirmed DPN. Original and axonal nerve conduction study (NCS) sum z-scores were used as indicators of the severity of DPN and peripheral nerve damage.
39 (21.9%) participants had DPN. Serum NfL (s-NfL) was significantly higher in participants with DPN (18.8 ng/L [IQR 14.4; 27.9]) than in participants without DPN (15.4 ng/L [IQR 11.7; 20.1]). There were no unadjusted s-NfL differences between controls (17.6 ng/L [IQR 12.7; 19.8]) and participants with or without DPN. Higher original and axonal NCS sum z-scores were associated with 10% higher s-NfL (10.2 and 12.1% [95% CI's 4.0; 16.8 and 6.6; 17.9] per 1 SD). The AUC of s-NfL for DPN was 0.63 (95% CI 0.52; 0.73).
S-NfL is unlikely to be a reliable biomarker for the presence of DPN. S-NfL is however associated tothe severity of the nerve damage underlying DPN.
研究神经丝轻链（NfL）与糖尿病多发性神经病（DPN）的存在和严重程度之间的关系。
我们对来自丹麦 ADDITION-Denmark 队列的 178 名经屏幕筛查的 2 型糖尿病患者和 32 名健康对照者的横断面数据进行了分析。使用单分子阵列分析生物库血清样本中的 NfL。根据多伦多标准定义 DPN 为确诊 DPN。原始和轴突神经传导研究（NCS）总和 z 评分被用作 DPN 和周围神经损伤严重程度的指标。
39（21.9%）名参与者患有 DPN。患有 DPN 的参与者血清 NfL（s-NfL）（18.8ng/L [IQR 14.4; 27.9]）明显高于未患有 DPN 的参与者（15.4ng/L [IQR 11.7; 20.1]）。未校正的 s-NfL 在对照组（17.6ng/L [IQR 12.7; 19.8]）和有或无 DPN 的参与者之间没有差异。较高的原始和轴突 NCS 总和 z 评分与 s-NfL 升高 10%相关（10.2%和 12.1%[95%CI 4.0; 16.8 和 6.6; 17.9]每 1 SD）。s-NfL 对 DPN 的 AUC 为 0.63（95%CI 0.52; 0.73）。
s-NfL 不太可能成为 DPN 存在的可靠生物标志物。然而，s-NfL 与 DPN 潜在神经损伤的严重程度相关。
