Zhu Xi-Wei, Ye Hao, Pan Yi-Yun, Wu Yanan, Wu Xin-Xing
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, P. R. China.
J Org Chem. 2024 Mar 1;89(5):3471-3480. doi: 10.1021/acs.joc.3c02898. Epub 2024 Feb 13.
A Pd-catalyzed thiocarbonylative cyclization of N-(-iodoaryl)acrylamides with easily accessible thioformates has been developed. The reaction has a wide substrate scope with good yields and represents a powerful route to the synthesis of thioester-functionalized oxindoles. Both -aryl and alkyl thioformates as the thioester sources were well tolerated. The active Pd-CO intermediate may play an important role in the transformation process.
已开发出一种钯催化的N-（-碘芳基）丙烯酰胺与易于获得的硫代甲酸酯的硫羰基化环化反应。该反应具有广泛的底物范围，产率良好，是合成硫酯官能化氧化吲哚的有效途径。作为硫酯源的芳基和烷基硫代甲酸酯均能良好耐受。活性钯-一氧化碳中间体可能在转化过程中起重要作用。
