School of Science, Anhui Agricultural University, Hefei, 230036, P. R. China.
Org Lett. 2022 Oct 21;24(41):7555-7559. doi: 10.1021/acs.orglett.2c02953. Epub 2022 Oct 10.
Herein we reported a novel approach to synthesize thioesters with -aryl thioformates as thioester sources. The reaction proceeded at ambient temperature using widely available starting ingredients, wherein the thioester moiety was smoothly transferred to aryl iodides from -aryl thioformates. A variety of substrates with various electronic natures were all tolerated under the reaction conditions to furnish desirable thioesters in ranges from moderate to excellent yields. The gram-scale reaction was also conducted, and there was virtually little change in chemical yield, indicating that large-scale synthesis of thioesters may be viable using this method.
在这里，我们报道了一种用 -芳基硫代甲酸酯作为硫酯源合成硫酯的新方法。该反应在环境温度下进行，使用广泛可用的起始原料，其中硫酯部分从 -芳基硫代甲酸酯中顺利转移到芳基碘化物。各种具有不同电子性质的底物在反应条件下都能耐受，以中等至优异的收率得到所需的硫酯。克级规模的反应也进行了，化学收率几乎没有变化，表明该方法可能适用于硫酯的大规模合成。
