State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Nano Lett. 2024 Feb 28;24(8):2619-2628. doi: 10.1021/acs.nanolett.3c04977. Epub 2024 Feb 13.
Post-extraction alveolar bone atrophy greatly hinders the subsequent orthodontic tooth movement (OTM) or implant placement. In this study, we synthesized biodegradable bifunctional bioactive calcium phosphorus nanoflowers (NFs) loaded with abaloparatide (ABL), namely ABL@NFs, to achieve spatiotemporal management for alveolar bone regeneration. The NFs exhibited a porous hierarchical structure, high drug encapsulation efficacy, and desirable biocompatibility. ABL was initially released to recruit stem cells, followed by sustained release of Ca and PO for interface mineralization, establishing an osteogenic "biomineralized environment". ABL@NFs successfully restored morphologically and functionally active alveolar bone without affecting OTM. In conclusion, the ABL@NFs demonstrated promising outcomes for bone regeneration under orthodontic condition, which might provide a desirable reference of man-made "bone powder" in the hard tissue regeneration field.
拔牙后牙槽骨萎缩极大地阻碍了随后的正畸牙齿移动（OTM）或种植体植入。在这项研究中，我们合成了载有阿巴洛肽（ABL）的可生物降解双功能生物活性钙磷纳米花（NFs），即 ABL@NFs，以实现牙槽骨再生的时空管理。NFs 具有多孔的层次结构、高药物包封效率和良好的生物相容性。ABL 首先被释放以募集干细胞，随后持续释放 Ca 和 PO 以进行界面矿化，从而建立成骨的“生物矿化环境”。ABL@NFs 成功地恢复了形态和功能活跃的牙槽骨，而不会影响 OTM。总之，ABL@NFs 在正畸条件下显示出有希望的骨再生结果，这可能为硬组织再生领域提供了理想的人造“骨粉”参考。
