Hussain Md Sadique, Shaikh Nusrat K, Agrawal Mohit, Tufail Muhammad, Bisht Ajay Singh, Khurana Navneet, Kumar Rajesh
Department of Pharmacology, School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan 302017, India.
Department of Quality Assurance, Smt. N. M. Padalia Pharmacy College, Ahmedabad, 382210 Gujarat, India.
Pathol Res Pract. 2024 Mar;255:155186. doi: 10.1016/j.prp.2024.155186. Epub 2024 Feb 2.
Osteomyelitis, a debilitating bone infection, presents considerable clinical challenges due to its intricate etiology and limited treatment options. Despite strides in surgical and chemotherapeutic interventions, the treatment landscape for osteomyelitis remains unsatisfactory. Recent attention has focused on the role of non-coding RNAs (ncRNAs) in the pathogenesis and progression of osteomyelitis. This review consolidates current knowledge on the involvement of distinct classes of ncRNAs, including microRNAs, long ncRNAs, and circular RNAs, in the context of osteomyelitis. Emerging evidence from various studies underscores the potential of ncRNAs in orchestrating gene expression and influencing the differentiation of osteoblasts and osteoclasts, pivotal processes in bone formation. The review initiates by elucidating the regulatory functions of ncRNAs in fundamental cellular processes such as inflammation, immune response, and bone remodeling, pivotal in osteomyelitis pathology. It delves into the intricate network of interactions between ncRNAs and their target genes, illuminating how dysregulation contributes to the establishment and persistence of osteomyelitic infections. Understanding their regulatory roles may pave the way for targeted diagnostic tools and innovative therapeutic interventions, promising a paradigm shift in the clinical approach to this challenging condition. Additionally, we delve into the promising therapeutic applications of these molecules, envisioning novel diagnostic and treatment approaches to enhance the management of this challenging bone infection.
骨髓炎是一种使人衰弱的骨感染，由于其病因复杂且治疗选择有限，带来了相当大的临床挑战。尽管在手术和化疗干预方面取得了进展，但骨髓炎的治疗前景仍不尽人意。最近的关注焦点集中在非编码RNA（ncRNA）在骨髓炎发病机制和进展中的作用。本综述整合了关于不同类型ncRNA（包括微小RNA、长链ncRNA和环状RNA）在骨髓炎背景下所起作用的现有知识。来自各种研究的新证据强调了ncRNA在协调基因表达以及影响成骨细胞和破骨细胞分化（骨形成中的关键过程）方面的潜力。该综述首先阐明了ncRNA在炎症、免疫反应和骨重塑等基本细胞过程中的调节功能，这些过程在骨髓炎病理中至关重要。它深入探讨了ncRNA与其靶基因之间复杂的相互作用网络，揭示了失调如何导致骨髓炎感染的发生和持续。了解它们的调节作用可能为靶向诊断工具和创新治疗干预铺平道路，有望在针对这种具有挑战性病症的临床方法上实现范式转变。此外，我们深入探讨了这些分子有前景的治疗应用，设想新颖的诊断和治疗方法以加强对这种具有挑战性的骨感染的管理。
