Demir Ömer Furkan, Balyimez Ayşe Dilara
Department of Cardiology, Bursa Postgraduate Hospital, Bursa, Turkey.
Int J Angiol. 2023 Jul 15;33(1):15-21. doi: 10.1055/s-0043-1771251. eCollection 2024 Feb.
A new index called the acute-to-chronic (A/C) glycemic ratio has been proposed to better represent the true acute glycemic rise in people with acute disease. However, there has been no previous study investigating the relationship between A/C glycemic ratio and SYNTAX score in patients with diabetic acute coronary syndrome (ACS). The aim of this study is to evaluate the role of A/C glycemic ratio in predicting coronary artery disease severity and SYNTAX score in diabetic patients presenting with ACS. The study included 131 consecutive patients hospitalized for ACS in our hospital, previously diagnosed with diabetes and undergoing percutaneous coronary intervention. The relationship between A/C glycemic ratio and SYNTAX score calculated at the time of admission was determined in univariate and multivariate linear regression analyses. The sample size was divided into three parts (T1, T2, and T3) according to the admission blood glucose (ABG)/estimated average glucose (eAG) ratio. When ABG/eAG and SYNTAX scores were compared, there was no significant difference between the T1 and T2 groups, but a significant increase was found in the T3 group compared with the other two groups (T1: 14.26, T2: 14.77, T3: 24.41; < 0.001). When multivariate modeling was performed with the two or three most relevant variables (age, estimated glomerular filtration rate [eGFR], and ABG/eAG ratio), the upper tertile of the ABG/eAG variable was correlated with the severity of coronary atherosclerosis and higher SYNTAX score. This study shows that there is a significant relationship between higher ABG/eAG ratio and higher SYNTAX score in diabetic patients presenting with ACS.
一种名为急性与慢性（A/C）血糖比值的新指标已被提出，以更好地反映急性疾病患者真正的急性血糖升高情况。然而，此前尚无研究调查糖尿病急性冠状动脉综合征（ACS）患者的A/C血糖比值与SYNTAX评分之间的关系。本研究的目的是评估A/C血糖比值在预测糖尿病合并ACS患者的冠状动脉疾病严重程度和SYNTAX评分中的作用。该研究纳入了我院131例因ACS住院、先前已诊断为糖尿病并接受经皮冠状动脉介入治疗的连续患者。在单变量和多变量线性回归分析中确定了入院时计算的A/C血糖比值与SYNTAX评分之间的关系。根据入院血糖（ABG）/估计平均血糖（eAG）比值将样本量分为三部分（T1、T2和T3）。比较ABG/eAG和SYNTAX评分时，T1组和T2组之间无显著差异，但T3组与其他两组相比有显著升高（T1：14.26，T2：14.77，T3：24.41；<0.001）。当使用两个或三个最相关变量（年龄、估计肾小球滤过率[eGFR]和ABG/eAG比值）进行多变量建模时，ABG/eAG变量的上三分位数与冠状动脉粥样硬化的严重程度和更高的SYNTAX评分相关。本研究表明，糖尿病合并ACS患者中较高的ABG/eAG比值与较高的SYNTAX评分之间存在显著关系。
