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改良应激性高血糖率在预测糖尿病患者单纯冠状动脉搭桥术后早期肺炎中的预测作用。

The predictive role of modified stress hyperglycemia rate in predicting early pneumonia after isolated coronary bypass surgery in patients with diabetes mellitus.

作者信息

As Ahmet Kağan, Engin Mesut

机构信息

Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.

出版信息

Biomol Biomed. 2025 Jan 14;25(2):505-510. doi: 10.17305/bb.2024.10330.

Abstract

Postoperative pneumonia (PP) is one of the most serious complications following coronary artery bypass graft (CABG) surgery. The recently developed admission blood glucose (ABG)/estimated average glucose (eAG) ratio has been identified as a prognostic marker in cardiovascular diseases. This study aimed to investigate the predictive role of the modified ABG/eAG (mABG/eAG) ratio in the development of pneumonia during the early postoperative period in diabetic patients undergoing CABG surgery. In this single-center study, diabetic patients who underwent isolated coronary bypass surgery at the Training and Research Hospital between 1 January 2018 and 1 January 2023 were included. Patients who did not develop PP were assigned to the control group, while those who developed PP were assigned to the PP group. A total of 549 patients were included in the study, 478 patients in the control group (median age = 58 years [range 35-81]) and 71 patients in the PP group (median age = 63 years [37-86]). In the multivariate analysis, the use of packed blood products (odds ratio [OR] = 1.685, 95% confidence interval [CI]: 1.453 - 1.892; P = 0.027), mABG/eAG ratio (OR = 1.659, 95% CI: 1.190 - 2.397; P = 0.019), and re-intubation (OR = 1.829, 95% CI: 1.656 - 1.945; P = 0.034) were identified as independent predictors for the development of PP. Our findings demonstrate that the mABG/eAG ratio is an independent predictor of PP in diabetic patients undergoing CABG surgery. Based on our results, high-risk patients can be identified by calculating the mABG/eAG ratio.

摘要

术后肺炎(PP)是冠状动脉旁路移植术(CABG)后最严重的并发症之一。最近开发的入院血糖(ABG)/估计平均血糖(eAG)比值已被确定为心血管疾病的预后标志物。本研究旨在探讨改良的ABG/eAG(mABG/eAG)比值在接受CABG手术的糖尿病患者术后早期肺炎发生中的预测作用。在这项单中心研究中,纳入了2018年1月1日至2023年1月1日期间在培训与研究医院接受单纯冠状动脉搭桥手术的糖尿病患者。未发生PP的患者被分配到对照组,而发生PP的患者被分配到PP组。共有549例患者纳入研究,对照组478例(中位年龄 = 58岁[范围35 - 81岁]),PP组71例(中位年龄 = 63岁[37 - 86岁])。在多变量分析中,使用浓缩血液制品(比值比[OR] = 1.685,95%置信区间[CI]:1.453 - 1.892;P = 0.027)、mABG/eAG比值(OR = 1.659,95%CI:1.190 - 2.397;P = 0.019)和再次插管(OR = 1.829,95%CI:1.656 - 1.945;P = 0.034)被确定为PP发生的独立预测因素。我们的研究结果表明,mABG/eAG比值是接受CABG手术的糖尿病患者发生PP的独立预测因素。根据我们的结果,可以通过计算mABG/eAG比值来识别高危患者。

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