As Ahmet Kağan, Engin Mesut
Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.
Biomol Biomed. 2025 Jan 14;25(2):505-510. doi: 10.17305/bb.2024.10330.
Postoperative pneumonia (PP) is one of the most serious complications following coronary artery bypass graft (CABG) surgery. The recently developed admission blood glucose (ABG)/estimated average glucose (eAG) ratio has been identified as a prognostic marker in cardiovascular diseases. This study aimed to investigate the predictive role of the modified ABG/eAG (mABG/eAG) ratio in the development of pneumonia during the early postoperative period in diabetic patients undergoing CABG surgery. In this single-center study, diabetic patients who underwent isolated coronary bypass surgery at the Training and Research Hospital between 1 January 2018 and 1 January 2023 were included. Patients who did not develop PP were assigned to the control group, while those who developed PP were assigned to the PP group. A total of 549 patients were included in the study, 478 patients in the control group (median age = 58 years [range 35-81]) and 71 patients in the PP group (median age = 63 years [37-86]). In the multivariate analysis, the use of packed blood products (odds ratio [OR] = 1.685, 95% confidence interval [CI]: 1.453 - 1.892; P = 0.027), mABG/eAG ratio (OR = 1.659, 95% CI: 1.190 - 2.397; P = 0.019), and re-intubation (OR = 1.829, 95% CI: 1.656 - 1.945; P = 0.034) were identified as independent predictors for the development of PP. Our findings demonstrate that the mABG/eAG ratio is an independent predictor of PP in diabetic patients undergoing CABG surgery. Based on our results, high-risk patients can be identified by calculating the mABG/eAG ratio.
术后肺炎(PP)是冠状动脉旁路移植术(CABG)后最严重的并发症之一。最近开发的入院血糖(ABG)/估计平均血糖(eAG)比值已被确定为心血管疾病的预后标志物。本研究旨在探讨改良的ABG/eAG(mABG/eAG)比值在接受CABG手术的糖尿病患者术后早期肺炎发生中的预测作用。在这项单中心研究中,纳入了2018年1月1日至2023年1月1日期间在培训与研究医院接受单纯冠状动脉搭桥手术的糖尿病患者。未发生PP的患者被分配到对照组,而发生PP的患者被分配到PP组。共有549例患者纳入研究,对照组478例(中位年龄 = 58岁[范围35 - 81岁]),PP组71例(中位年龄 = 63岁[37 - 86岁])。在多变量分析中,使用浓缩血液制品(比值比[OR] = 1.685,95%置信区间[CI]:1.453 - 1.892;P = 0.027)、mABG/eAG比值(OR = 1.659,95%CI:1.190 - 2.397;P = 0.019)和再次插管(OR = 1.829,95%CI:1.656 - 1.945;P = 0.034)被确定为PP发生的独立预测因素。我们的研究结果表明,mABG/eAG比值是接受CABG手术的糖尿病患者发生PP的独立预测因素。根据我们的结果,可以通过计算mABG/eAG比值来识别高危患者。