[Evaluation of the secretory activity of the adrenal cortex and gonads in women with epilepsy. II. Urinary excretion of estrogen fractions and alpha and beta pregnanediol during the 2 days preceding menstrual bleeding].

In 32 women with epileptic seizures related in time to the premenstrual phase (group A) and 31 women with seizures unrelated to this phase (group B) oestrone oestradiol and oestriol and progesterone metabolites (alpha and beta-pregnanediol) were determined in 24-hour urine. The investigations were carried out during 2 days preceding the onset of menstrual bleeding usually during three successive cycles. A significant reduction was observed in the amounts of all three oestrogen fractions in relation to normal values on both days (without any significant difference between the groups). Women with epilepsy excreted 56-60% less oestrogens than healthy women. Similarly the levels of alpha and beta-pregnanediol were significantly below the accepted normal range. The obtained results are insufficient for accepting the role of oestrogens in the development of lowered convulsive threshold on the days preceding menstrual bleeding. On the other hand, it may be concluded that progesterone deficiency may have an effect on the appearance of greater readiness to seizures before menstruation in epileptic women.