连接蛋白家族：结构、功能与临床意义。

Cingulin family: Structure, function and clinical significance.

机构信息

Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine, Guangzhou, Guangdong 510006, China.

Center for Pancreatic Cancer Research, The South China University of Technology School of Medicine, Guangzhou, Guangdong 510006, China; The Second Affiliated Hospital and Guangzhou First People's Hospital, South China University of Technology School of Medicine, Guangdong 510006, China; The South China University of Technology Comprehensive Cancer Center, Guangzhou, Guangdong 510006, China.

出版信息

Life Sci. 2024 Mar 15;341:122504. doi: 10.1016/j.lfs.2024.122504. Epub 2024 Feb 13.

DOI:10.1016/j.lfs.2024.122504

PMID:38354973

Abstract

Cingulin and its paralog paracingulin are vital components of the apical junctional complex in vertebrate epithelial and endothelial cells. They are both found in tight junctions (TJ), and paracingulin is also detectable in adherens junctions (AJ) as TJ cytoplasmic plaque proteins. Cingulin and paracingulin interact with other proteins to perform functions. They interact with cytoskeletal proteins, modulate the activity of small GTPases, such as RhoA and Rac1, and regulate gene expression. In addition, cingulin and paracingulin regulate barrier function and many pathological processes, including inflammation and tumorigenesis. In this review, we summarize the discovery and structure, expression and subcellular distribution, and molecular interactions of cingulin family proteins and discuss their role in development, physiology, and pathological processes.

摘要

桥连蛋白及其旁系同源蛋白副桥连蛋白是脊椎动物上皮细胞和内皮细胞顶端连接复合体的重要组成部分。它们都存在于紧密连接（TJ）中，副桥连蛋白也可以作为 TJ 细胞质斑蛋白在黏着连接（AJ）中检测到。桥连蛋白和副桥连蛋白通过相互作用来执行功能。它们与细胞骨架蛋白相互作用，调节小 GTP 酶（如 RhoA 和 Rac1）的活性，并调节基因表达。此外，桥连蛋白和副桥连蛋白调节屏障功能和许多病理过程，包括炎症和肿瘤发生。在这篇综述中，我们总结了桥连蛋白家族蛋白的发现和结构、表达和亚细胞分布以及分子相互作用，并讨论了它们在发育、生理和病理过程中的作用。