Guo Gangqiang, Lin Yutong, Zhu Xinqi, Ding Feng, Xue Xiangyang, Zhang Qingfeng
Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research and Precision Medicine, Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Institute of Tropical Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
First Clinical College, Wenzhou Medical University, Wenzhou, China.
Trends Parasitol. 2024 Mar;40(3):214-229. doi: 10.1016/j.pt.2024.01.006. Epub 2024 Feb 13.
RNA modifications (epitranscriptome) - such as N6-methyladenosine (m6A), 5-methylcytosine (m5C), and pseudouridine (Ψ) - modulate RNA processing, stability, interaction, and translation, thereby playing critical roles in the development, replication, virulence, metabolism, and life cycle adaptations of parasitic protozoa. Here, we summarize potential homologs of the major human RNA modification regulatory factors in parasites, outline current knowledge on how RNA modifications affect parasitic protozoa, highlight the regulation of RNA modifications and their crosstalk, and discuss current progress in exploring RNA modifications as potential drug targets. This review contributes to our understanding of epitranscriptomic regulation of parasitic protozoa biology and pathogenesis and provides new perspectives for the treatment of parasitic diseases.
RNA修饰（表观转录组）——如N6-甲基腺苷（m6A）、5-甲基胞嘧啶（m5C）和假尿苷（Ψ）——可调节RNA的加工、稳定性、相互作用和翻译，从而在寄生原生动物的发育、复制、毒力、代谢和生命周期适应中发挥关键作用。在此，我们总结了寄生虫中主要人类RNA修饰调节因子的潜在同源物，概述了关于RNA修饰如何影响寄生原生动物的现有知识，强调了RNA修饰的调控及其相互作用，并讨论了将RNA修饰作为潜在药物靶点探索的当前进展。本综述有助于我们理解寄生原生动物生物学和发病机制的表观转录组调控，并为寄生虫病的治疗提供新的视角。
