Lépine Charles, Trinquet Aude, Laé Marick, Costes-Martineau Valérie
Service d'anatomie et cytologie pathologiques, Nantes université, CHU de Nantes, 44000 Nantes, France; Inserm, CNRS, Immunology and New Concepts in ImmunoTherapy (INCIT), UMR 1302/EMR6001, Nantes, France.
Service d'anatomie et cytologie pathologiques, CHU de Montpellier, 34295 Montpellier, France.
Ann Pathol. 2025 Jan;45(1):43-52. doi: 10.1016/j.annpat.2023.12.013. Epub 2024 Feb 13.
In recent years, several nasal cavity and sinus entities have been described with fusion genes. Salivary gland tumors with fusion genes will not be discussed in this article, but it should be kept in mind that accessory salivary glands are present in the nasal cavity and sinuses and can therefore lead to tumoral lesions. Entities with specific or more frequently described rearrangements in the nasal cavities and sinuses are DEK::AFF2 squamous cell carcinomas,;non-intestinal and non-salivary nasosinusal adenocarcinomas, some of which displaying ETV6 gene rearrangements; biphenotypic nasosinusal sarcomas, most of which displaying PAX3 gene rearrangements; and Ewing's adamantinoma-like sarcomas, which display the same rearrangements as conventional Ewing's sarcomas, mainly the EWSR1::FLI1 rearrangement. Each entity will be described morphologically, immunohistochemically, and prognostically.
近年来,已有多种鼻腔和鼻窦病变被描述为具有融合基因。本文将不讨论具有融合基因的唾液腺肿瘤,但应记住鼻腔和鼻窦中存在副唾液腺,因此可能导致肿瘤性病变。鼻腔和鼻窦中具有特定或更常见重排的病变包括DEK::AFF2鳞状细胞癌;非肠型和非唾液型鼻窦腺癌,其中一些显示ETV6基因重排;双表型鼻窦肉瘤,其中大多数显示PAX3基因重排;以及尤因氏牙釉质瘤样肉瘤,其显示与传统尤因氏肉瘤相同的重排,主要是EWSR1::FLI1重排。将从形态学、免疫组织化学和预后方面对每种病变进行描述。