Department of Surgery, Japanese Red Cross Kumamoto Hospital, 2-1-1 Nagamine Minami, Higashi-ku, Kumamoto, 861-8520, Japan.
Department of Nephrology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Sci Rep. 2024 Feb 14;14(1):3715. doi: 10.1038/s41598-024-54163-0.
Increased water intake is recommended for kidney transplant recipients; however, its efficacy remains controversial. We hypothesized that pre-existing histological findings of the allograft might modulate the impact of water intake. We retrospectively analyzed 167 adults with living-donor kidney transplants (April 2011-May 2020; median observation period, 77 months) whose baseline biopsy data were available. We compared the chronic-change group (n = 38) with the control group (n = 129) to assess the impact of self-reported daily water intake on the estimated glomerular filtration rate (eGFR). The range distribution of water intake was as follows: - 1000 ml (n = 4), 1000-1500 ml (n = 23), 1500-2000 ml (n = 64), 2000-2500 ml (n = 57), 2500-3000 ml (n = 16), and 3000 - ml (n = 3). Donor age was significantly higher in the chronic-change group. In the control group, the ΔeGFR/year increase was correlated with water intake. However, the increase in the water intake of the chronic-change group significantly decreased ΔeGFR/year (1000-1500 ml: + 1.95 ml/min/1.73 m and > 2000 ml: - 1.92 ml/min/1.73 m, p = 0.014). This study suggested a potential influence of increased water intake on recipients with marginal grafts in living donor kidney transplantation.
建议肾移植受者增加水分摄入;然而，其疗效仍存在争议。我们假设同种异体移植物的预先存在的组织学发现可能会调节水分摄入的影响。我们回顾性分析了 167 名接受活体供肾移植的成年人(2011 年 4 月至 2020 年 5 月;中位观察期为 77 个月)，他们的基线活检数据可用。我们比较了慢性改变组(n=38)和对照组(n=129)，以评估自我报告的每日水分摄入对估算肾小球滤过率(eGFR)的影响。水分摄入的范围分布如下:-1000ml(n=4)、1000-1500ml(n=23)、1500-2000ml(n=64)、2000-2500ml(n=57)、2500-3000ml(n=16)和 3000-ml(n=3)。慢性改变组的供体年龄明显较高。在对照组中，eGFR/年的增加与水分摄入相关。然而，慢性改变组的水分摄入增加显著降低了 eGFR/年的增加(1000-1500ml:+1.95ml/min/1.73m 和>2000ml:-1.92ml/min/1.73m，p=0.014)。本研究提示在活体供肾移植中，增加水分摄入对边缘移植物的受者可能有潜在影响。
