Institute of Integrative Medicine, Qingdao University, Qingdao, Shandong, China.
Shandong Provincial Sports Center, Shandong Administration of Sports, Jinan, Shandong, China.
Front Endocrinol (Lausanne). 2024 Jan 31;15:1301529. doi: 10.3389/fendo.2024.1301529. eCollection 2024.
This study aims to investigate the relationship between skeletal muscle and left ventricular mass (LVM) in patients with hyperthyroidism, providing theoretical and data-based foundations for further research on the interaction between secondary muscle atrophy and cardiac remodeling.
A retrospective data collection was conducted, including 136 patients with hyperthyroidism (Study group) and 50 healthy participants (control group). The Study group was further divided into Group A (high LVM) and Group B (low LVM) based on LVM size. Multiple linear regression analysis was performed to examine the correlation between skeletal muscle and LVM, with model evaluation. Based on the results, further nonlinear regression analysis was conducted to explore the detailed relationship between skeletal muscle and LVM.
Compared to the control group, the Study group exhibited significantly lower LVM, skeletal muscle mass index (SMI), and skeletal muscle mass (SMM) (<0.05). Within the subgroups, Group A had significantly higher SMI, SMM, and hand grip strength compared to Group B (<0.05). The results of the multiple linear regression showed a certain correlation between SMI (=0.60, =0.042, =0.021.17) and hand grip strength (=0.34, =0.045, =0.010.67) with LVM. However, the residuals of the multiple regression did not follow a normal distribution (K-S=2.50, P<0.01). Further results from a generalized linear model and structural equation modeling regression also demonstrated a correlation between SMI (=0.60, =0.040, =0.031.17) (=0.60, =0.042, =0.021.17) and hand grip strength (=0.34, =0.043, =0.010.67) (=0.34, =0.045, =0.010.67) with LVM.
Patients with hyperthyroidism may exhibit simultaneous decreases in LVM, SMM, and SMI. The LVM in patients is correlated with SMM and hand grip strength, highlighting the need for further exploration of the causal relationship and underlying mechanisms. These findings provide a basis for the prevention and treatment of secondary sarcopenia and cardiac pathology in patients with hyperthyroidism.
本研究旨在探讨甲状腺功能亢进症患者骨骼肌与左心室质量（LVM）之间的关系，为进一步研究继发性肌肉萎缩与心脏重构之间的相互作用提供理论和数据基础。
回顾性收集了 136 例甲状腺功能亢进症患者（研究组）和 50 例健康参与者（对照组）的数据。根据 LVM 大小，将研究组进一步分为 A 组（高 LVM）和 B 组（低 LVM）。采用多元线性回归分析骨骼肌与 LVM 的相关性，并进行模型评估。基于结果，进一步进行非线性回归分析，以探讨骨骼肌与 LVM 之间的详细关系。
与对照组相比，研究组的 LVM、骨骼肌质量指数（SMI）和骨骼肌质量（SMM）显著降低（<0.05）。在亚组中，A 组的 SMI、SMM 和握力均显著高于 B 组（<0.05）。多元线性回归的结果表明，SMI（=0.60，=0.042，=0.021.17）和握力（=0.34，=0.045，=0.010.67）与 LVM 之间存在一定的相关性。然而，多元回归的残差不符合正态分布（K-S=2.50，P<0.01）。广义线性模型和结构方程模型回归的进一步结果也表明，SMI（=0.60，=0.040，=0.031.17）（=0.60，=0.042，=0.021.17）和握力（=0.34，=0.043，=0.010.67）（=0.34，=0.045，=0.010.67）与 LVM 之间存在相关性。
甲状腺功能亢进症患者可能同时出现 LVM、SMM 和 SMI 降低。患者的 LVM 与 SMM 和握力相关，提示需要进一步探讨因果关系和潜在机制。这些发现为预防和治疗甲状腺功能亢进症患者的继发性肌肉减少症和心脏病理提供了依据。
