负压封闭引流联合开放式植骨或骨搬运治疗胫骨创伤性骨髓炎及其对血清 CRP、TNF-α和 IL-6 水平的影响。
Treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone migration and its effect on the levels of CRP, TNF-α and IL-6 in the serum.
机构信息
Department of third Orthopaedics, The 903 Hospital of the Chinese people's Liberation Army, Hangzhou,310004, China.
出版信息
Afr Health Sci. 2023 Sep;23(3):481-485. doi: 10.4314/ahs.v23i3.55.
OBJECTIVE
To observe the effect of negative pressure closure drainage combined with open bone grafting or bone migration in the treatment of tibial traumatic osteomyelitis.
METHODS
Eighty-six (86) cases of tibial traumatic osteomyelitis admitted to Hospital of the Chinese people's Liberation Army from September 2017 to September 2018 were randomly divided into control group and observation group, forty-three (43) cases each. Debridement, open bone grafting or bone migration was given to the control group.The observation group was treated with negative pressure closed drainage on the basis of the control group. In addition, the serum components such as CRP, TNF-α, IL-6 of the control group and observation group were detected respectively after surgery.
RESULTS
Observation group granulation cover wound, fracture healing time was shorter than the control group, fracture healing rate was better than the control group, the difference has statistical significance (P<0.05). By comparing serum CRP, TNF-α, IL-6 levels before and after treatment in the two groups, it was found that the observation group was lower than the control group (P<0.05, respectively). Serum CRP, TNF-α, IL-6 levels were significantly (P<0.05).
CONCLUSION
The treatment of tibial traumatic osteomyelitis with negative pressure closure drainage combined with open bone grafting or bone displacement has a good effect on fracture healing and is worth popularizing.
目的
观察负压封闭引流联合开放植骨或骨搬运治疗胫骨创伤性骨髓炎的效果。
方法
选取 2017 年 9 月至 2018 年 9 月解放军医院收治的胫骨创伤性骨髓炎患者 86 例，随机分为对照组和观察组，每组 43 例。对照组给予清创术联合开放植骨或骨搬运治疗，观察组在对照组基础上采用负压封闭引流治疗。比较两组患者的临床疗效、愈合时间、愈合率及血清 C 反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）等炎症因子水平。
结果
观察组肉芽覆盖创面、骨折愈合时间短于对照组，骨折愈合率优于对照组，差异均有统计学意义（P<0.05）。比较两组患者治疗前后的血清 CRP、TNF-α、IL-6 水平，观察组均低于对照组，差异均有统计学意义（P<0.05）。
结论
负压封闭引流联合开放植骨或骨搬运治疗胫骨创伤性骨髓炎可促进骨折愈合，效果较好，值得临床推广应用。
Zotero 插件