细菌肺炎模型中的噬菌体疗法：系统评价与荟萃分析
Phage Therapy in Bacterial Pneumonia Models: A Systematic Review and Meta-Analysis.
作者信息
Rahman Mohammad Akhlaquer, Verma Kapil Kumar, Posa Mahesh Kumar
机构信息
Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, 21944, Kingdom of Saudi Arabia.
Minerva College of Pharmacy, Indora, HP, 176402, India.
出版信息
Comb Chem High Throughput Screen. 2025;28(3):447-452. doi: 10.2174/0113862073267755240126111628.
BACKGROUND
Phage therapy could play an important role in the bacterial pneumonia. However, the exact role of phage therapy in bacterial pneumonia is unclear to date.
AIM
The current study aims to find out the role of phage therapy in preclinical models of bacterial pneumonia.
METHODS
The studies were searched in databases with proper MeSH terms along with Boolean operators and selected based on eligibility criteria as per the PRISMA guidelines. The Odd Ratio (OR) was calculated with a 95% confidence interval and the heterogeneity was also calculated. The funnel plot was used to conduct a qualitative examination of publication bias.
RESULTS
The OR was observed to be 0.11 (0.04, 0.27)] after 24 hrs, 0.11 [0.03, 0.34] after 7 days and 0.04 [0.01, 0.15] after 10 days that showed a significant role of phage therapy in reduction of deaths in the bacterial pneumonia models as compared to the placebo group. However, after 48hrs, a non-significant reduction was observed.
CONCLUSION
There was a significant role of phage therapy in the reduction of deaths in the bacterial pneumonia models.
背景
噬菌体疗法可能在细菌性肺炎中发挥重要作用。然而，迄今为止，噬菌体疗法在细菌性肺炎中的确切作用尚不清楚。
目的
本研究旨在探讨噬菌体疗法在细菌性肺炎临床前模型中的作用。
方法
使用适当的医学主题词（MeSH）术语以及布尔运算符在数据库中检索研究，并根据PRISMA指南的纳入标准进行选择。计算比值比（OR）及其95%置信区间，并计算异质性。采用漏斗图对发表偏倚进行定性检验。
结果
24小时后观察到的OR为0.11（0.04，0.27），7天后为0.11（0.03，0.34），10天后为0.04（0.01，0.15），这表明与安慰剂组相比，噬菌体疗法在降低细菌性肺炎模型中的死亡率方面具有显著作用。然而，48小时后，观察到的降低不显著。
结论
噬菌体疗法在降低细菌性肺炎模型的死亡率方面具有显著作用。
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