Chemistry and Biotechnology Research Group (QUIBIO), School of Basic Sciences, Universidad Santiago de Cali, Pampalinda Campus Calle 5 # 62-00, Santiago de Cali 76001, Colombia.
Microbiology, Industry and Environment Research Group (GIMIA), School of Basic Sciences, Universidad Santiago de Cali, Pampalinda Campus Calle 5 # 62-00, Santiago de Cali 76001, Colombia.
Int J Mol Sci. 2022 Apr 21;23(9):4577. doi: 10.3390/ijms23094577.
Bacteriophages offer an alternative for the treatment of multidrug-resistant bacterial diseases as their mechanism of action differs from that of antibiotics. However, their application in the clinical field is limited to specific cases of patients with few or no other alternative therapies. This systematic review assesses the effectiveness and safety of phage therapy against multidrug-resistant bacteria through the evaluation of studies published over the past decade. To that end, a bibliographic search was carried out in the PubMed, Science Direct, and Google Scholar databases. Of the 1500 studies found, 27 met the inclusion criteria, with a total of 165 treated patients. Treatment effectiveness, defined as the reduction in or elimination of the bacterial load, was 85%. Except for two patients who died from causes unrelated to phage therapy, no serious adverse events were reported. This shows that phage therapy could be an alternative treatment for patients with infections associated with multidrug-resistant bacteria. However, owing to the phage specificity required for the treatment of various bacterial strains, this therapy must be personalized in terms of bacteriophage type, route of administration, and dosage.
噬菌体为治疗多重耐药细菌疾病提供了一种替代方法，因为它们的作用机制与抗生素不同。然而，它们在临床领域的应用仅限于少数或没有其他替代疗法的患者的特定情况。本系统评价通过评估过去十年发表的研究，评估了噬菌体治疗对多重耐药菌的有效性和安全性。为此，在 PubMed、Science Direct 和 Google Scholar 数据库中进行了文献检索。在发现的 1500 项研究中，有 27 项符合纳入标准，共有 165 名接受治疗的患者。治疗效果（定义为细菌负荷减少或消除）为 85%。除了两名因与噬菌体治疗无关的原因而死亡的患者外，没有报告严重的不良事件。这表明噬菌体治疗可能是治疗与多重耐药菌相关感染的一种替代方法。然而，由于治疗各种细菌菌株所需的噬菌体特异性，这种治疗方法必须在噬菌体类型、给药途径和剂量方面进行个性化。
