Department of Anatomic Pathology, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria.
Department of Histopathology, University of Uyo Teaching Hospital, Uyo, Akwa Ibom, Nigeria.
Ann Afr Med. 2023 Oct-Dec;22(4):501-507. doi: 10.4103/aam.aam_180_22.
Gastrointestinal stromal tumors (GISTs) are neoplastic lesions that primarily affect the digestive tract and develop from interstitial cells of Cajal. These lesions require histopathological and immunohistochemical characterization due to their malignant potential and personalized treatment. In this investigation, the sex, age, lesional sites of origin, histopathological types, the prevalence of human epidermal growth factor receptors (HER-2) expression, prognostic indices (based on tumor size and mitotic figures), expression of CD117 and DOG1, and characteristics of patients with GIST were all characterized.
This was a retrospective cross-sectional analysis of GIST cases seen at four tertiary health-care centers in Nigeria over a 10-year period (2008-2017) and investigated utilizing histopathological and immunohistochemical (CD117, DOG1, and HER-2) methods.
In this investigation, there were twenty GIST cases. Notably, the majority (40%) of the cases had tumors with sizes between 7.0 and 8.0 cm; the stomach was the most frequent site (70%) and the spindle cell type of GIST was the most prevalent (80%) histopathological type. In addition, the stomach was significantly associated with GIST as an origin site (with a P = 0.001), and 100% and 50% of these tumors were immunoreactive with CD117 and DOG1, respectively.
In our study, GISTs most frequently develop in the stomach, and CD117 and DOG1 are essential for correctly diagnosing these tumors. However, HER-2 immunoreactivity is a predictive marker of survival for personalized care.
胃肠道间质瘤（GISTs）是一种主要影响消化道并起源于 Cajal 间质细胞的肿瘤病变。由于其恶性潜能和个体化治疗的需要，这些病变需要进行组织病理学和免疫组织化学特征分析。在本研究中，对 GIST 的性别、年龄、病变起源部位、组织病理学类型、人表皮生长因子受体（HER-2）表达的流行率、预后指标（基于肿瘤大小和有丝分裂象）、CD117 和 DOG1 的表达以及患者特征进行了分析。
这是一项回顾性的横断面对尼日利亚四家三级医疗保健中心在 10 年内（2008-2017 年）观察到的 GIST 病例的分析，利用组织病理学和免疫组织化学（CD117、DOG1 和 HER-2）方法进行了研究。
在本研究中，有 20 例 GIST 病例。值得注意的是，大多数（40%）病例的肿瘤大小在 7.0 到 8.0 厘米之间；胃是最常见的部位（70%），梭形细胞型 GIST 是最常见的组织病理学类型（80%）。此外，胃与 GIST 的起源部位显著相关（P=0.001），这些肿瘤中有 100%和 50%分别对 CD117 和 DOG1 呈免疫反应性。
在我们的研究中，GISTs 最常发生在胃中，CD117 和 DOG1 是正确诊断这些肿瘤的关键。然而，HER-2 免疫反应性是个性化治疗中预测生存的一个标志物。
