Zhang Yingyin, Feng Qingyuan, Zheng Yu, Lu Yanju, Liao Saihu, Huang Shenlin
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing, Jiangsu 210037, China.
State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen, Fujian 361005, China.
Org Lett. 2024 Feb 23;26(7):1410-1415. doi: 10.1021/acs.orglett.4c00010. Epub 2024 Feb 15.
A radical hydro-fluorosulfonylation of propargyl alcohols with FSOCl is presented based on the photoactivation of the electron donor-acceptor (EDA) complex. The reaction avoids the requirement for photocatalysts, bases, hydrogen donor reagents, any other additives, and harsh conditions, enabling the facile synthesis of various functionalized γ-hydroxy ()-alkenylsulfonyl fluorides. These multifunctional sulfonyl fluorides can be further diversified, providing access to various privileged molecules of biological relevance.
基于电子供体-受体（EDA）络合物的光活化作用，实现了炔丙醇与氟磺酰氯的自由基氢氟磺酰化反应。该反应无需光催化剂、碱、氢供体试剂、任何其他添加剂以及苛刻的条件，能够简便地合成各种功能化的γ-羟基（）-烯基磺酰氟。这些多功能磺酰氟可以进一步多样化，从而获得各种具有生物学相关性的特权分子。
