Heart Beat Science Lab Inc., Sendai, Japan.
Gifu Mates Sleep Clinic, Gifu, Japan.
Sleep Breath. 2024 Jun;28(3):1273-1283. doi: 10.1007/s11325-024-02991-9. Epub 2024 Feb 15.
This study aimed to develop an unobtrusive method for home sleep apnea testing (HSAT) utilizing micromotion signals obtained by a piezoelectric rubber sheet sensor.
Algorithms were designated to extract respiratory and ballistocardiogram components from micromotion signals and to detect respiratory events as the characteristic separation of the fast envelope of the respiration component from the slow envelope. In 78 adults with diagnosed or suspected sleep apnea, micromotion signal was recorded with a piezoelectric rubber sheet sensor placed beneath the bedsheet during polysomnography. In a half of the subjects, the algorithms were optimized to calculate respiratory event index (REI), estimating apnea-hypopnea index (AHI). In the other half of subjects, the performance of REI in classifying sleep apnea severity was evaluated. Additionally, the predictive value of the frequency of cyclic variation in heart rate (Fcv) obtained from the ballistocardiogram was assessed.
In the training group, the optimized REI showed a strong correlation with the AHI (r = 0.93). Using the optimal cutoff of REI ≥ 14/h, subjects with an AHI ≥ 15 were identified with 77.8% sensitivity and 90.5% specificity. When applying this REI to the test group, it correlated closely with the AHI (r = 0.92) and identified subjects with an AHI ≥ 15 with 87.5% sensitivity and 91.3% specificity. While Fcv showed a modest correlation with AHI (r = 0.46 and 0.66 in the training and test groups), it lacked independent predictive power for AHI.
The analysis of respiratory component of micromotion using piezoelectric rubber sheet sensors presents a promising approach for HSAT, providing a practical and effective means of estimating sleep apnea severity.
本研究旨在开发一种利用压电橡胶片传感器获取的微运动信号进行家庭睡眠呼吸暂停测试(HSAT)的非侵入性方法。
设计算法从微运动信号中提取呼吸和心冲击图成分,并通过呼吸成分的快速包络与慢包络的特征分离来检测呼吸事件。在 78 名被诊断或疑似患有睡眠呼吸暂停的成年人中,在多导睡眠图期间,将压电橡胶片传感器放置在床单下记录微运动信号。在一半的受试者中,优化算法以计算呼吸事件指数(REI),估计呼吸暂停低通气指数(AHI)。在另一半受试者中,评估 REI 在分类睡眠呼吸暂停严重程度方面的性能。此外,还评估了从心冲击图获得的心率循环变化频率(Fcv)的预测价值。
在训练组中,优化后的 REI 与 AHI 呈强相关性(r=0.93)。使用 REI≥14/h 的最佳截断值,可识别 AHI≥15 的受试者,其灵敏度为 77.8%,特异性为 90.5%。当将此 REI 应用于测试组时,它与 AHI 密切相关(r=0.92),并以 87.5%的灵敏度和 91.3%的特异性识别 AHI≥15 的受试者。虽然 Fcv 与 AHI 呈中度相关性(r=0.46 和 0.66 在训练组和测试组中),但它缺乏对 AHI 的独立预测能力。
使用压电橡胶片传感器分析微运动的呼吸成分,为 HSAT 提供了一种很有前途的方法,为估计睡眠呼吸暂停的严重程度提供了一种实用有效的手段。