State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. of China.
Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, Jilin, P.R. of China.
Biomacromolecules. 2024 Mar 11;25(3):1972-1977. doi: 10.1021/acs.biomac.3c01370. Epub 2024 Feb 15.
A facile and green approach for the preparation of PEG-NHs from PEG-Ns in water with DTT as the reduction reagent has been developed, avoiding the introduction of metal ions and difficulties in purification compared to the traditional synthesis process of PEG-NHs. A series of high-purity linear and multiarm PEG-NHs with different molecular weights were synthesized, demonstrating the versatility of this method. Additionally, HS-PEG-NH with high fidelity of thiol and amine was easily prepared through the one-step two functional group conversion of N-PEG-S-S-PEG-N, and the PEG-based NH-PEG@AuNPs were also prepared. This technology will promote the application of PEG-NHs in the fields of medicine and biomaterials.
一种简便、绿色的方法，以 DTT 作为还原剂，从 PEG-Ns 在水中制备 PEG-NHs，避免了传统的 PEG-NHs 合成过程中金属离子的引入和纯化困难。合成了一系列具有不同分子量的高纯度线性和多臂 PEG-NHs，证明了该方法的通用性。此外，通过 N-PEG-S-S-PEG-N 的一步两步官能团转化，很容易制备出具有高保真度巯基和胺基的 HS-PEG-NH，并且还制备了基于 PEG 的 NH-PEG@AuNPs。这项技术将促进 PEG-NHs 在医学和生物材料领域的应用。
