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关于呼和浩特市感染新冠病毒奥密克戎变异株的 COVID-19 患者临床严重程度和流行病学分析的回顾性研究。

Retrospective study about clinical severity and epidemiological analysis of the COVID-19 Omicron subvariant lineage-infected patients in Hohhot, China.

机构信息

Clinical Laboratory Department, Hohhot First Hospital, Hohhot, 010000, China.

Hohhot Dian Medical Laboratory, Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Dian Diagnostics Group Co., Ltd. No, 329 Jin Peng Street, Xihu District, Hangzhou, Zhejiang Province, 310030, China.

出版信息

BMC Infect Dis. 2024 Feb 15;24(1):206. doi: 10.1186/s12879-024-09084-8.

DOI:10.1186/s12879-024-09084-8
PMID:38360539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10870667/
Abstract

BACKGROUND

Fear of a global public health issue and fresh infection wave in the persistent COVID-19 pandemic has been enflamed by the appearance of the novel variant Omicron BF.7 lineage. Recently, it has been seeing the novel Omicron subtype BF.7 lineage has sprawled exponentially in Hohhot. More than anything, risk stratification is significant to ascertain patients infected with COVID-19 who the most need in-hospital or in-home management. The study intends to understand the clinical severity and epidemiological characteristics of COVID-19 Omicron subvariant BF.7. lineage via gathering and analyzing the cases with Omicron subvariant in Hohhot, Inner Mongolia.

METHODS

Based upon this, we linked variant Omicron BF.7 individual-level information including sex, age, symptom, underlying conditions and vaccination record. Further, we divided the cases into various groups and assessed the severity of patients according to the symptoms of patients with COVID-19. Clinical indicators and data might help to predict disadvantage outcomes and progression among Omicron BF.7 patients.

RESULTS

In this study, in patients with severe symptoms, some indicators from real world data such as white blood cells, AST, ALT and CRE in patients with Omicron BF.7 in severe symptoms were significantly higher than mild and asymptomatic patients, while some indicators were significantly lower.

CONCLUSIONS

Above results suggested that the indicators were associated with ponderance of clinical symptoms. Our survey emphasized the value of timely investigations of clinical data obtained by systemic study to acquire detailed information.

摘要

背景

新型变异株奥密克戎 BF.7 谱系的出现,加剧了人们对持续的 COVID-19 大流行中全球公共卫生问题和新感染浪潮的恐惧。最近,呼和浩特市新型奥密克戎亚型 BF.7 谱系呈指数级蔓延。最重要的是,风险分层对于确定 COVID-19 感染患者中最需要住院或居家管理的患者非常重要。本研究旨在通过收集和分析内蒙古呼和浩特市奥密克戎亚变异株病例,了解 COVID-19 奥密克戎亚变异株 BF.7 谱系的临床严重程度和流行病学特征。

方法

基于此,我们链接了变异株奥密克戎 BF.7 的个体水平信息,包括性别、年龄、症状、基础疾病和疫苗接种记录。进一步将病例分为不同组,并根据 COVID-19 患者的症状评估患者的严重程度。临床指标和数据可能有助于预测奥密克戎 BF.7 患者的不良结局和进展。

结果

在这项研究中,在症状严重的患者中,一些来自真实世界数据的指标,如严重症状的奥密克戎 BF.7 患者的白细胞、AST、ALT 和 CRE,明显高于轻症和无症状患者,而一些指标明显较低。

结论

上述结果表明,这些指标与临床症状的严重程度有关。我们的调查强调了及时调查系统研究获得的临床数据的价值,以获取详细信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/c7e27f373eac/12879_2024_9084_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/6d710d002e43/12879_2024_9084_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/8fccdd3cdae2/12879_2024_9084_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/4d9312d24de6/12879_2024_9084_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/a6971ea287f1/12879_2024_9084_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/ef86c4107324/12879_2024_9084_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/c7e27f373eac/12879_2024_9084_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/6d710d002e43/12879_2024_9084_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/8fccdd3cdae2/12879_2024_9084_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/4d9312d24de6/12879_2024_9084_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/a6971ea287f1/12879_2024_9084_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/ef86c4107324/12879_2024_9084_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0208/10870667/c7e27f373eac/12879_2024_9084_Fig6_HTML.jpg

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