单细胞浸润和细胞核直径在早期口腔舌鳞癌中的预后作用。
The prognostic role of single cell invasion and nuclear diameter in early oral tongue squamous cell carcinoma.
机构信息
Department of Pathology, University of Helsinki, FI-00014, Helsinki, Haartmaninkatu, P.O. Box 21, Finland.
Institute of Biomedicine, Pathology, University of Turku, Turku, Finland.
出版信息
BMC Cancer. 2024 Feb 15;24(1):213. doi: 10.1186/s12885-024-11954-y.
BACKGROUND
The clinical significance of single cell invasion and large nuclear diameter is not well documented in early-stage oral tongue squamous cell carcinoma (OTSCC).
METHODS
We used hematoxylin and eosin-stained sections to evaluate the presence of single cell invasion and large nuclei in a multicenter cohort of 311 cases treated for early-stage OTSCC.
RESULTS
Single cell invasion was associated in multivariable analysis with poor disease-specific survival (DSS) with a hazard ratio (HR) of 2.089 (95% CI 1.224-3.566, P = 0.007), as well as with disease-free survival (DFS) with a HR of 1.666 (95% CI 1.080-2.571, P = 0.021). Furthermore, large nuclei were associated with worse DSS (HR 2.070, 95% CI 1.216-3.523, P = 0.007) and with DFS in multivariable analysis (HR 1.645, 95% CI 1.067-2.538, P = 0.024).
CONCLUSION
Single cell invasion and large nuclei can be utilized for classifying early OTSCC into risk groups.
背景
在早期口腔舌鳞状细胞癌（OTSCC）中，单细胞浸润和细胞核直径较大的临床意义尚未得到充分证实。
方法
我们使用苏木精-伊红染色切片，在一个多中心队列的 311 例早期 OTSCC 治疗病例中，评估单细胞浸润和大细胞核的存在情况。
结果
多变量分析显示，单细胞浸润与疾病特异性生存（DSS）不良相关，风险比（HR）为 2.089（95%CI 1.224-3.566，P=0.007），与无病生存（DFS）相关，HR 为 1.666（95%CI 1.080-2.571，P=0.021）。此外，大细胞核与较差的 DSS（HR 2.070，95%CI 1.216-3.523，P=0.007）和多变量分析中的 DFS 相关（HR 1.645，95%CI 1.067-2.538，P=0.024）。
结论
单细胞浸润和大细胞核可用于将早期 OTSCC 分为风险组。
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