Department of Surgical Oncology, Centre Léon Bérard, Lyon, France.
INSERM 1296 Unit, Radiations: Defense, Health and Environment, Centre Léon Bérard, Lyon, France.
Int J Cancer. 2022 Apr 15;150(8):1301-1309. doi: 10.1002/ijc.33896. Epub 2021 Dec 24.
While head and neck cancer incidence decreased worldwide due to reduced tobacco and alcohol consumption, oral tongue cancer (OTC) incidence has been reported to be increasing in several countries. Our study examines the incidence trends of OTC in France from 1990 to 2018, globally and by age; and compares the incidence trends with the evolution of the incidence of other human papilloma virus-unrelated head and neck squamous cell carcinoma, that is, cancers of the remaining subsites of the oral cavity (RSOCC) and laryngeal cancers for the period 1990 to 2018. World age-standardized incidence rates of oral tongue cancers (C02), cancers of the remaining subsites of the oral cavity (RSOCC, C03-06) and laryngeal cancers (C32) were estimated using the French National Network of Cancer Registries for the period 1990 to 2018. Trends in national incidence rates were estimated from a mixed-effect Poisson model including age and year effects using penalized splines and a district-random effect. In women aged 30 and 40, a significant increase in OTC incidence was observed, while ROSCC showed a nonsignificant incidence decrease. In young men aged 25, a marginally significant increase of OTC incidence years was observed, while incidence rates of RSOCC significantly declined. The results suggest a tendency towards diverging incidence trends for OTC compared to RSOCC and laryngeal cancer in young adults. The observed trends may reflect changes in underlying exposures or emerging exposures not yet identified, and stress the need to further investigate the etiology of oral tongue cancers.
尽管由于烟草和酒精消费的减少，全球范围内头颈部癌症的发病率有所下降，但据报道，一些国家的口腔舌癌（OTC）发病率呈上升趋势。我们的研究检查了 1990 年至 2018 年法国口腔舌癌的发病率趋势，包括全球和按年龄划分的趋势；并将这些趋势与同期其他与人类乳头瘤病毒无关的头颈部鳞状细胞癌（即口腔其余部位癌症和喉癌）的发病率变化进行了比较，这些癌症发病率数据可追溯至 1990 年至 2018 年。1990 年至 2018 年期间，使用法国国家癌症登记网络，估计了口腔舌癌（C02）、口腔其余部位癌症（RSOCC，C03-06）和喉癌（C32）的全球年龄标准化发病率。通过包含年龄和年份效果的混合效应泊松模型，使用惩罚样条和地区随机效应，估计了国家发病率趋势。在 30 岁和 40 岁的女性中，观察到 OTC 发病率显著上升，而 ROSCC 则显示发病率无显著下降。在 25 岁的年轻男性中，OTC 发病率略有上升，而 RSOCC 的发病率则显著下降。结果表明，与 RSOCC 和喉癌相比，年轻人中 OTC 的发病率趋势存在趋异的趋势。观察到的趋势可能反映了潜在暴露或尚未确定的新出现暴露的变化，并强调需要进一步研究口腔舌癌的病因。
