Department of Medicine-Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Department of Neonatology, Paramitha Women and Children's Hospital, Hyderabad, India.
J Perinatol. 2024 Sep;44(9):1252-1257. doi: 10.1038/s41372-024-01904-8. Epub 2024 Feb 15.
Nasal Intermittent Positive Pressure Ventilation (NIPPV) is an effective therapy for infants in respiratory distress. We here report the safety of a novel, low-cost, non-electric bubble NIPPV device in comparison with bubble NCPAP.
At Paramitha Children's Hospital (Hyderabad, India), preterm (n = 60) neonates with moderate respiratory distress were pragmatically allocated to bubble NCPAP (5-8 cm HO) or bubble NIPPV (P 8-12 cm HO/P 5-8 cm HO) based on staff and equipment availability. Primary outcomes to assess safety included clinically relevant pneumothorax, nasal septal necrosis, or abdominal distention.
One patient in each arm developed minor nasal septal injury (grade 3 on NCPAP, grade 2 on NIPPV); no patients in either arm developed a clinically significant pneumothorax or abdominal distention.
The similar rates of nasal septal injury, pneumothorax and abdominal distention suggest that bubble NIPPV has a similar safety profile as bubble NCPAP for preterm infants in respiratory distress.
鼻内间歇正压通气（NIPPV）是治疗呼吸窘迫婴儿的有效方法。我们在此报告一种新型、低成本、非电动气泡 NIPPV 设备与气泡 CPAP 相比的安全性。
在 Paramitha 儿童医院（印度海得拉巴），根据医护人员和设备的可用性，对患有中度呼吸窘迫的早产儿（n=60）进行实用分组，给予气泡 CPAP（5-8cm H2O）或气泡 NIPPV（P 8-12cm H2O/P 5-8cm H2O）。评估安全性的主要结局包括临床相关气胸、鼻中隔坏死或腹胀。
每组各有 1 名患者出现轻微鼻中隔损伤（CPAP 为 3 级，NIPPV 为 2 级）；两组均无患者发生临床显著气胸或腹胀。
鼻中隔损伤、气胸和腹胀的发生率相似，表明在呼吸窘迫的早产儿中，气泡 NIPPV 与气泡 CPAP 的安全性相当。
