Asanuma Y, Fujiya S, Ide H, Agishi Y
Diabetes Res Clin Pract. 1985 Aug;1(2):95-101. doi: 10.1016/s0168-8227(85)80034-6.
The incidence of pulmonary diseases among diabetics in Japan has been found to be more than 50% at death. This suggests the existence of some pulmonary risk factors. We analyzed pulmonary functions in 50 diabetics (31 males and 19 females) without overt lung disease, compared to 21 healthy male subjects of the same age (around 50 years old). Forced vital capacity and timed vital capacity were lower in diabetics (P less than 0.005). Diffusing capacity was also decreased in male diabetics (P less than 0.05). Among diabetics, a decrease in the diffusing capacity was dominant in patients with diabetic retinopathy, which correlated with an increasing duration of their diabetes. Analysis by the partial correlation method which accounts for the smoking index showed that standardized indices for peripheral airflow in male diabetics decreased significantly as the patient's age increased (P less than 0.005); the rate of decrement was greater than that of the control subjects. Diabetic patients showed abnormal lung function in the peripheral airways which increased with age and gas transfer was also affected by diabetic microangiopathy as well as the duration of diabetes. These changes seemed to deteriorate progressively, possibly combining and contributing to respiratory insufficiency in critical pathological conditions.
据发现，在日本，糖尿病患者中肺部疾病的发病率在死亡时超过50%。这表明存在一些肺部危险因素。我们分析了50名无明显肺部疾病的糖尿病患者（31名男性和19名女性）的肺功能，并与21名同龄（约50岁）健康男性受试者进行了比较。糖尿病患者的用力肺活量和定时肺活量较低（P<0.005）。男性糖尿病患者的弥散能力也有所下降（P<0.05）。在糖尿病患者中，糖尿病视网膜病变患者的弥散能力下降最为明显，这与糖尿病病程的延长相关。通过考虑吸烟指数的偏相关方法分析表明，男性糖尿病患者外周气流的标准化指标随着患者年龄的增加而显著下降（P<0.005）；下降速率大于对照组。糖尿病患者外周气道的肺功能异常随年龄增加，气体交换也受到糖尿病微血管病变以及糖尿病病程的影响。这些变化似乎会逐渐恶化，在严重病理状态下可能共同导致呼吸功能不全。
