Assistant Professor, Department of Physiology, Gsl Medical College , Rajahmundry-Andhra Pradesh, India .
J Clin Diagn Res. 2013 Aug;7(8):1606-8. doi: 10.7860/JCDR/2013/6182.3237. Epub 2013 Aug 1.
The complications which are associated with type 2 Diabetes mellitus are mostly caused by macro vascular and micro vascular damages. The pulmonary complications of diabetes mellitus have been poorly characterised. The present study has focused on the mechanical aspects of lung dysfunction which are attributable to type 2 Diabetes Mellitus; maximal forced Spiro metric Pulmonary Function Tests (PFTs) like Forced vital capacity (FVC), Forced Expiratory Volume in 1sec (FEV1),. FEV1/FVC % and Peak expiratory flow rate (PEFR), to be specific.
Spirometry was performed by using a computerised electronic spirometer, (RMS Helios 401, version 3-1-59, transducer number 4-16-1669) on 40 type 2 diabetics who were between 40-65 years of age and on 40 controls (who were matched for age, sex and BMI). Any person with a H/O smoking or any condition which affected the lung functions, was excluded from the study. The study was a cross sectional and a retrospective study. Data was analyzed and processed with the help of EPI INFO statistical software by using unpaired Student's 't'-test (two-tailed). The level of significance was taken as a p-value of <0.025.
This study clearly showed a statistically significant reduction in FVC, FEV1, PEFR in type 2 diabetics as compared to those in the controls. FEV1/FVC% was increased in type 2 diabetics as compared to that in controls and the increase was statistically significant.
This study concluded that type 2 diabetes adversely affects the mechanical functions of the lung, the pattern of disease being primarily restrictive in nature.
2型糖尿病相关并发症大多由大血管和微血管损伤引起。糖尿病的肺部并发症一直未得到充分描述。本研究聚焦于2型糖尿病所致肺功能障碍的机械方面；具体而言，是最大用力肺量计肺功能测试（PFTs），如用力肺活量（FVC）、第1秒用力呼气量（FEV1）、FEV1/FVC%和呼气峰值流速（PEFR）。
使用计算机化电子肺量计（RMS Helios 401，版本3 - 1 - 59，传感器编号4 - 16 - 1669）对40名年龄在40 - 65岁的2型糖尿病患者和40名对照者（年龄、性别和BMI匹配）进行肺量计检查。任何有吸烟史或任何影响肺功能的疾病的人都被排除在研究之外。该研究为横断面回顾性研究。借助EPI INFO统计软件，使用非配对学生t检验（双侧）对数据进行分析和处理。显著性水平取p值<0.025。
本研究清楚地表明，与对照组相比，2型糖尿病患者的FVC、FEV1、PEFR在统计学上有显著降低。与对照组相比，2型糖尿病患者的FEV1/FVC%升高，且升高具有统计学意义。
本研究得出结论，2型糖尿病对肺的机械功能有不利影响，疾病模式主要为限制性。
