Bertelli A, Giovannini L, Romano M R, Maltinti G, Dell'Osso L, Bertelli A A
Drugs Exp Clin Res. 1985;11(4):269-73.
Rat kidney was perfused using Krebs solution containing 3 or 6 mEq/l lithium or 3 or 6 mEq/l rubidium; the histological lesions thus induced were compared. Rubidium-induced lesions, irrespective of concentrations, consisted of tubular dilations, degeneration and necrosis very similar to those induced by lower concentrations of lithium; moreover, Bowman space alterations were observed. In contrast, lithium-induced damage was dose-dependent: 6 mEq/l solution induced severe tubular damage with necrosis, endoluminal cellular debris and hyaline substance.
用含有3或6毫当量/升锂或3或6毫当量/升铷的 Krebs 溶液灌注大鼠肾脏；比较由此诱导产生的组织学损伤。铷诱导的损伤，无论浓度如何，均表现为肾小管扩张、变性和坏死，与低浓度锂诱导的损伤非常相似；此外，还观察到肾小囊间隙改变。相比之下，锂诱导的损伤呈剂量依赖性：6毫当量/升的溶液诱导严重的肾小管损伤，伴有坏死、管腔内细胞碎片和透明物质。
